Freund Ophir, Rotem-Green Michal, Rahat Maya, Gershman Evgeni, Ophir Noa, Fireman Elizabeth, Shenhar-Tsarfaty Shani, Bar-Shai Amir
The Institute of Pulmonary Medicine, Tel-Aviv Sourasky Medical Center & Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 6423906, Israel.
Internal Medicine C, Tel Aviv Sourasky Medical Center & Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 6423906, Israel.
Nanomedicine (Lond). 2023 Feb;18(4):303-315. doi: 10.2217/nnm-2022-0269. Epub 2023 Mar 28.
To evaluate the role of nanoparticles (NP) in sputum samples of active smokers as markers of inflammation and disease. 29 active smokers were included (14 with chronic obstructive pulmonary disease [COPD]) and underwent clinical assessment, pulmonary function tests, sputum induction (with NP analysis) and blood sampling. Higher particle and NP concentrations and smaller mean size directly correlated with clinical parameters such as the COPD Assessment Test score and impulse oscillometry results. Similar correlations were found between NPs and increased sputum IL-1β, IL-6 and TNF-α. Among COPD patients, higher IL-8 and lower IL-10 serum levels also correlated with NP concentrations. This proof-of-concept study shows the potential of sputum NPs as markers of airway inflammation and disease.
评估纳米颗粒（NP）在现吸烟者痰液样本中作为炎症和疾病标志物的作用。纳入了29名现吸烟者（14名患有慢性阻塞性肺疾病[COPD]），并对其进行了临床评估、肺功能测试、痰液诱导（并分析NP）和血液采样。更高的颗粒和NP浓度以及更小的平均尺寸与诸如COPD评估测试评分和脉冲振荡法结果等临床参数直接相关。在NP与痰液中白细胞介素-1β、白细胞介素-6和肿瘤坏死因子-α升高之间也发现了类似的相关性。在COPD患者中，更高的白细胞介素-8血清水平和更低的白细胞介素-10血清水平也与NP浓度相关。这项概念验证研究表明痰液NP作为气道炎症和疾病标志物的潜力。
