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食用陆生植物和海洋大型藻类红藻和绿藻提取物的抗菌潜力概述。

An Overview on Antimicrobial Potential of Edible Terrestrial Plants and Marine Macroalgae Rhodophyta and Chlorophyta Extracts.

机构信息

University of Coimbra, MARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Department of Life Sciences, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal.

Department of Biology, CESAM-Centre for Environmental and Marine Studies, University of Aveiro, 3810-193 Aveiro, Portugal.

出版信息

Mar Drugs. 2023 Feb 28;21(3):163. doi: 10.3390/md21030163.

Abstract

Antibiotics are used to prevent and treat bacterial infections. After a prolonged use of antibiotics, it may happen that bacteria adapt to their presence, developing antibiotic resistance and bringing up health complications. Nowadays, antibiotic resistance is one of the biggest threats to global health and food security; therefore, scientists have been searching for new classes of antibiotic compounds which naturally express antimicrobial activity. In recent decades, research has been focused on the extraction of plant compounds to treat microbial infections. Plants are potential sources of biological compounds that express several biological functions beneficial for our organism, including antimicrobial activity. The high variety of compounds of natural origin makes it possible to have a great bioavailability of antibacterial molecules to prevent different infections. The antimicrobial activity of marine plants, also called seaweeds or macroalgae, for both Gram-positive and Gram-negative, and several other strains infective for humans, has been proven. The present review presents research focused on the extraction of antimicrobial compounds from red and green macroalgae (domain Eukarya, kingdom Plantae). Nevertheless, further research is needed to verify the action of macroalgae compounds against bacteria in vitro and in vivo, to be involved in the production of safe and novel antibiotics.

摘要

抗生素用于预防和治疗细菌感染。经过长时间的使用抗生素,细菌可能会适应它们的存在,从而产生抗生素耐药性,并引发健康并发症。如今,抗生素耐药性是全球健康和食品安全的最大威胁之一;因此,科学家们一直在寻找具有天然抗菌活性的新型抗生素化合物。近几十年来,研究的重点一直是从植物中提取化合物来治疗微生物感染。植物是表达对我们机体有益的多种生物功能的生物化合物的潜在来源,包括抗菌活性。天然来源的化合物种类繁多,使得具有高生物利用度的抗菌分子能够预防多种感染成为可能。海洋植物(也称为海藻或大型藻类)对革兰氏阳性和革兰氏阴性菌以及其他几种对人类有感染性的菌株都具有抗菌活性,这一点已得到证实。本综述重点介绍了从红藻和绿藻(真核生物域,植物界)中提取抗菌化合物的研究。然而,还需要进一步的研究来验证海藻化合物在体外和体内对细菌的作用,以参与生产安全且新颖的抗生素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad3a/10058896/e2cea3befcd6/marinedrugs-21-00163-g001.jpg

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