血液白细胞中 Y 染色体镶嵌缺失：对男性健康的影响。
Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men's Health.
机构信息
Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Laboratory of Cardiovascular Mosaicism, National Cerebral and Cardiovascular Center, Osaka, Japan.
出版信息
Physiology (Bethesda). 2023 Jul 1;38(4):0. doi: 10.1152/physiol.00008.2023. Epub 2023 Mar 28.
Abstract
We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we discuss murine models and the potential mechanisms by which LOY contributes to disease.
摘要
我们简要介绍了血液中 Y 染色体丢失（LOY）的情况，并描述了已知的这种情况的风险因素。然后，我们综述了 LOY 与与年龄相关的疾病特征之间的关联。最后，我们讨论了小鼠模型以及 LOY 导致疾病的潜在机制。
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