草药膳食补充剂导致的肝毒性：过去、现在和未来。
Hepatotoxicity due to herbal dietary supplements: Past, present and the future.
机构信息
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, USA; Center for Dietary Supplement Research, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Department of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA; Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA; Center for Dietary Supplement Research, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
出版信息
Food Chem Toxicol. 2022 Nov;169:113445. doi: 10.1016/j.fct.2022.113445. Epub 2022 Sep 29.
Dietary supplements (DS) constitute a widely used group of products comprising vitamin, mineral, and botanical extract formulations. DS of botanical or herbal origins (HDS) comprise nearly 30% of all DS and are presented on the market either as single plant extracts or multi-extract-containing products. Despite generally safe toxicological profiles of most products currently present on the market, rising cases of liver injury caused by HDS - mostly by multi-ingredient and adulterated products - are of particular concern. Here we discuss the most prominent historical cases of HDS-induced hepatotoxicty - from Ephedra to Hydroxycut and OxyELITE Pro-NF, as well as products with suspected hepatotoxicity that are either currently on or are entering the market. We further provide discussion on overcoming the existing challenges with HDS-linked hepatotoxicity by introduction of advanced in silico, in vitro, in vivo, and microphysiological system approaches to address the matter of safety of those products before they reach the market.
膳食补充剂（DS）是一组广泛使用的产品，包括维生素、矿物质和植物提取物配方。植物或草药来源的 DS（HDS）占所有 DS 的近 30%，并以单一植物提取物或含有多种提取物的产品形式在市场上销售。尽管目前市场上大多数产品的毒理学特性通常是安全的，但 HDS 引起的肝损伤病例不断增加，尤其是由多种成分和掺假产品引起的肝损伤，这尤其令人担忧。在这里，我们讨论了 HDS 引起的肝毒性的一些最突出的历史案例——从麻黄到 Hydroxycut 和 OxyELITE Pro-NF，以及那些目前在市场上或即将进入市场的具有疑似肝毒性的产品。我们进一步讨论了通过引入先进的计算、体外、体内和微生理系统方法来克服与 HDS 相关的肝毒性的现有挑战，以解决这些产品在进入市场之前的安全性问题。
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