在中国西南部的猫中发现新型乳头瘤病毒。
The discovery of novel papillomaviruses in cats in Southwest China.
机构信息
College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, Chengdu, 610066, China.
出版信息
Virus Genes. 2023 Jun;59(3):484-488. doi: 10.1007/s11262-023-01989-x. Epub 2023 Mar 28.
Feline viral diarrhea is a significant cause of death in kittens. In this study, 12 mammalian viruses were identified by metagenomic sequencing in diarrheal feces in 2019, 2020, and 2021, respectively. Interestingly, a novel of felis catus papillomavirus (FcaPV) was identified for the first time in China. Subsequently, we investigated the prevalence of FcaPV in 252 feline samples, including 168 diarrheal feces and 84 oral swabs, with a total of 57 (22.62%, 57/252) samples detected positive. Of the 57 positive samples, FcaPV genotype 3 (FcaPV-3) was detected at high prevalence rate (68.42%, 39/57), followed by FcaPV-4 (22.8%, 13/57), FcaPV-2 (17.54%, 10/57), and FcaPV-1 (1.75%, 1/55), while no FcaPV-5 and FcaPV-6. In addition, two novel putative FcaPVs were identified, which were the highest similarity to Lambdapillomavirus from Leopardus wiedii or canis familiaris, respectively. Therefore, this study was the first characterization of the viral diversity in feline diarrheal feces and the prevalence of FcaPV in Southwest China.
猫传染性肠炎是导致幼猫死亡的重要原因。在这项研究中，通过宏基因组测序分别在 2019 年、2020 年和 2021 年的腹泻粪便中鉴定出了 12 种哺乳动物病毒。有趣的是，在中国首次鉴定出了一种新型猫疱疹病毒（FcaPV）。随后，我们调查了 252 份猫样本中的 FcaPV 流行情况，包括 168 份腹泻粪便和 84 份口腔拭子，共有 57 份（22.62%，57/252）样本检测呈阳性。在 57 份阳性样本中，FcaPV 基因型 3（FcaPV-3）的检出率较高（68.42%，39/57），其次是 FcaPV-4（22.8%，13/57）、FcaPV-2（17.54%，10/57）和 FcaPV-1（1.75%，1/55），而未检测到 FcaPV-5 和 FcaPV-6。此外，还鉴定出了两种新型推定的 FcaPV，它们与 Leopardus wiedii 或犬科的 Lambdapillomavirus 的相似度最高。因此，本研究首次对猫腹泻粪便中的病毒多样性和中国西南地区 FcaPV 的流行情况进行了特征描述。
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