School of Medicine, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
J Endocrinol Invest. 2023 Aug;46(8):1521-1531. doi: 10.1007/s40618-023-02069-5. Epub 2023 Mar 28.
The aim of this review was to summarize sex differences in glycolipid metabolic phenotypes of human and animal models after exposure to maternal hyperglycemia and overview the underlying mechanisms, providing a new perspective on the maternal hyperglycemia-triggered risk of glycolipidic disorders in offspring.
A comprehensive literature search within PubMed was performed. Selected publications related to studies on offspring exposed to maternal hyperglycemia investigating the sex differences of glycolipid metabolism were reviewed.
Maternal hyperglycemia increases the risk of glycolipid metabolic disorders in offspring, such as obesity, glucose intolerance and diabetes. Whether with or without intervention, metabolic phenotypes have been shown to exhibit sex differences between male and female offspring in response to maternal hyperglycemia, which may be related to gonadal hormones, organic intrinsic differences, placenta, and epigenetic modifications.
Sex may play a role in the different incidences and pathogenesis of abnormal glycolipid metabolism. More studies investigating both sexes are needed to understand how and why environmental conditions in early life affect long-term health between male and female individuals.
本综述旨在总结人类和动物模型在暴露于母体高血糖后糖脂代谢表型的性别差异，并概述潜在机制，为母体高血糖引发后代糖脂代谢紊乱的风险提供新视角。
在 PubMed 中进行了全面的文献检索。综述了与研究母体高血糖暴露后代糖脂代谢性别差异相关的选定出版物。
母体高血糖增加了后代糖脂代谢紊乱的风险，例如肥胖、葡萄糖耐量受损和糖尿病。无论是否干预，代谢表型均显示出雄性和雌性后代对母体高血糖的反应存在性别差异，这可能与性腺激素、有机内在差异、胎盘和表观遗传修饰有关。
性别可能在异常糖脂代谢的不同发生率和发病机制中起作用。需要更多研究两性来了解环境条件在生命早期如何以及为何影响男性和女性个体的长期健康。
