Sanberg P R, Bunsey M D, Hagenmeyer-Houser S H, Fine K E, Hillyer J G, Huntsman C S, Justice C A, McCann S A, McCoy D L, Monago J M
Brain Res. 1986 Mar 5;367(1-2):314-8. doi: 10.1016/0006-8993(86)91609-4.
Kainic acid-induced lesions (KAL) of the striatum produce body weight and regulatory deficits in the rat. Unlike lateral hypothalamic rats. KAL rats drink more during food deprivation and eat more afterwards as compared to both baseline conditions and control rats. The present study investigated these effects further. As in previous studies, food deprivation was found to cause polydipsia and increased postdeprivational food intake in the KAL animal. Urination and defecation, often used as an index of emotionality, were also found to increase under these conditions. When the antidiuretic hormone vasopressin was injected, all of these differences remained with the exception of postdeprivational feeding--KAL rats no longer ate more than controls. These findings suggest that psychogenic factors--but not hormonal influences--may play a primary role in the regulatory peculiarities seen in the KAL rat.
纹状体中由海藻酸诱导产生的损伤（KAL）会导致大鼠体重和调节功能出现缺陷。与下丘脑外侧损伤的大鼠不同，KAL大鼠在食物剥夺期间饮水更多，与基线条件和对照大鼠相比，之后进食也更多。本研究进一步探究了这些影响。与之前的研究一样，发现食物剥夺会导致KAL动物出现烦渴以及剥夺后食物摄入量增加。排尿和排便常被用作情绪指标，在这些条件下也会增加。注射抗利尿激素血管升压素后，除了剥夺后进食外，所有这些差异仍然存在——KAL大鼠不再比对照组吃得更多。这些发现表明，心理因素而非激素影响可能在KAL大鼠所表现出的调节特性中起主要作用。
