Bellinger L L, Williams F E
Am J Physiol. 1983 Mar;244(3):R389-99. doi: 10.1152/ajpregu.1983.244.3.R389.
Unlike rats which have electrolytic dorsomedial hypothalamic area lesions and are hypophagic and hypodipsic, the rats of the present study with dorsomedial hypothalamic area, kainic acid lesions (KAL) were postoperatively aphagic and adipsic. Subsequently, KAL rats rejected chow or a high-fat diet but ate a 30% sucrose-chow diet. Similarly the KAL rats were adipsic but drank a 30% sucrose solution. Slowly most of the KAL rats began to eat chow and drink tap water but remained hypophagic and hypodipsic. When tested for glucoprivic-induced feeding using 2-deoxy-D-glucose (200 or 400 mg/kg) the KAL rats, in contrast to the sham-operated controls, did not increase their food intake. During water deprivation the recovered KAL rats that would drink tap water ate, and following it they responded with an adequate increase in water consumption. During food deprivation the KAL rats, whether eating chow or sucrose-chow diet, drank, and subsequently the normally hypophagic rats actually ate more than the controls. Although the growth rate (linear and ponderal) of KAL rats was reduced compared with that of the controls, their body composition by indirect measurement was normal. The present data indicate that most of the dorsomedial hypothalamic syndrome results from damage to DMHA neurons and not to fibers of passage.
与那些下丘脑背内侧区有电解损伤且摄食减少和饮水减少的大鼠不同，本研究中下丘脑背内侧区有 kainic 酸损伤（KAL）的大鼠术后出现拒食和拒饮。随后，KAL 大鼠拒绝吃普通饲料或高脂饮食，但会吃 30%蔗糖-普通饲料饮食。同样，KAL 大鼠拒饮，但会喝 30%蔗糖溶液。慢慢地，大多数 KAL 大鼠开始吃普通饲料并饮用自来水，但仍摄食减少和饮水减少。当用 2-脱氧-D-葡萄糖（200 或 400mg/kg）测试糖缺乏诱导的摄食时，与假手术对照组相比，KAL 大鼠并未增加其食物摄入量。在缺水期间，恢复后会饮用自来水的 KAL 大鼠进食，随后其饮水量有适当增加。在缺食期间，KAL 大鼠，无论吃普通饲料还是蔗糖-普通饲料饮食，都会饮水，随后，通常摄食减少的大鼠实际上比对照组吃得更多。尽管 KAL 大鼠的生长速率（线性和体重）与对照组相比有所降低，但通过间接测量其身体成分是正常的。目前的数据表明，大多数下丘脑背内侧综合征是由 DMHA 神经元损伤而非传导纤维损伤引起的。
