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墨西哥慢性阻塞性肺疾病患者的定植情况

Colonization in Mexican Patients with Chronic Obstructive Pulmonary Disease.

作者信息

Plascencia-Cruz Marcela, Plascencia-Hernández Arturo, De Armas-Rodríguez Yaxsier, Cervantes-Guevara Gabino, Cervantes-Cardona Guillermo Alonso, Ramírez-Ochoa Sol, González-Ojeda Alejandro, Fuentes-Orozco Clotilde, Hernández-Mora Francisco Javier, González-Valencia Carlos Miguel, Pérez de Acha-Chávez Andrea, Cervantes-Pérez Enrique

机构信息

Department of Internal Medicine, Hospital Civil de Guadalajara "Fray Antonio Alcalde", Guadalajara 44280, Jalisco, Mexico.

Health Sciences University Center, Universidad de Guadalajara, Guadalajara 44100, Jalisco, Mexico.

出版信息

Trop Med Infect Dis. 2023 Feb 24;8(3):137. doi: 10.3390/tropicalmed8030137.

Abstract

The prevalence of colonization by () has not been studied in Mexico. We aimed to determine the prevalence of colonization by using molecular detection in a population of Mexican patients with chronic obstructive pulmonary disease (COPD) and describe their clinical and sociodemographic profiles. We enrolled patients discharged from our hospital diagnosed with COPD and without pneumonia ( = 15). The primary outcome of this study was colonization at the time of discharge, as detected by nested polymerase chain reaction (PCR) of oropharyngeal wash samples. The calculated prevalence of colonization for our study group was 26.66%. There were no statistically significant differences between COPD patients with and without colonization in our groups. Colonization of in patients with COPD is frequent in the Mexican population; the clinical significance, if any, remains to be determined. Oropharyngeal wash and nested PCR are excellent cost-effective options to simplify sample collection and detection in developing countries and can be used for further studies.

摘要

墨西哥尚未对()的定植率进行研究。我们旨在通过分子检测确定墨西哥慢性阻塞性肺疾病(COPD)患者群体中()的定植率,并描述他们的临床和社会人口统计学特征。我们纳入了我院出院的诊断为COPD且无肺炎的患者(n = 15)。本研究的主要结局是出院时通过咽拭子冲洗样本的巢式聚合酶链反应(PCR)检测到的()定植。我们研究组计算出的定植率为26.66%。我们组中定植和未定植的COPD患者之间无统计学显著差异。在墨西哥人群中,COPD患者中()的定植很常见;其临床意义(如果有的话)仍有待确定。咽拭子冲洗和巢式PCR是简化发展中国家样本采集和检测的优秀性价比选择,可用于进一步研究。

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COPD and the microbiome.慢性阻塞性肺疾病与微生物组。
Respirology. 2016 May;21(4):590-9. doi: 10.1111/resp.12732. Epub 2016 Jan 27.

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