Carranza-Rodríguez Cristina, López-Delgado Laura, Granados-Magan Álvaro, Pérez-Arellano José-Luis
Unidad de Enfermedades Infecciosas y Medicina Tropical, Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Departamento de Ciencias Médicas y Quirúrgicas, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Trop Med Infect Dis. 2023 Mar 20;8(3):181. doi: 10.3390/tropicalmed8030181.
infection is generally asymptomatic or mildly symptomatic, but in the immunosuppressed host, it is associated with more severe and complicated forms with a worse prognosis. seroprevalence was studied in 256 patients before receiving immunosuppressive treatment (before kidney transplantation or starting biological treatments). As a control group, serum bank data of 642 individuals representative of the population of the Canary Islands were retrospectively analyzed. To avoid false positives due to cross-reactivity with other similar helminth antigens present in the study area, IgG antibodies to spp. and spp. were evaluated in cases positive for . The data show this is a prevalent infection: 1.1% of the Canarian population, 2.38% of Canarian individuals awaiting organ transplants and 4.8% of individuals about to start biological agents. On the other hand, strongyloidiasis can remain asymptomatic (as observed in our study population). There are no indirect data, such as country of origin or eosinophilia, to help raise suspicion of the disease. In summary, our study suggests that screening for infection should be performed in patients who receive immunosuppressive treatment for solid organ transplantation or biological agents, in line with previous publications.
感染通常无症状或症状轻微,但在免疫抑制宿主中,它与更严重和复杂的形式相关,预后较差。在256例接受免疫抑制治疗前(肾移植前或开始生物治疗前)的患者中研究了血清阳性率。作为对照组,对代表加那利群岛人群的642人的血清库数据进行了回顾性分析。为避免因与研究区域存在的其他类似蠕虫抗原交叉反应导致的假阳性,对 spp. 和 spp. 的IgG抗体在 阳性病例中进行了评估。数据显示这是一种普遍感染:加那利群岛人群的1.1%、等待器官移植的加那利群岛个体的2.38%以及即将开始使用生物制剂的个体的4.8%。另一方面,类圆线虫病可保持无症状(如在我们的研究人群中观察到的)。没有诸如原籍国或嗜酸性粒细胞增多等间接数据来帮助提高对该病的怀疑。总之,我们的研究表明,根据先前的出版物,对于接受实体器官移植免疫抑制治疗或生物制剂治疗的患者,应进行 感染筛查。