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评估临床病理数据、特异性猫胰脂肪酶检测及腹部超声在猫胰腺炎严重程度判定中的作用

Evaluation of Clinicopathological Data, the Specific Feline Pancreatic Lipase Assay, and Abdominal Ultrasound as Severity Determinants in Cats with Pancreatitis.

作者信息

Buckley Christy, Lee Alison M, Wills Robert W, Sullivant Alyssa M, Cridge Harry

机构信息

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.

Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, MS 39762, USA.

出版信息

Vet Sci. 2023 Mar 10;10(3):209. doi: 10.3390/vetsci10030209.

Abstract

Limited data exist to predict the severity of pancreatitis in cats. In this retrospective case series, we reviewed the medical records of 45 cats with SP from June 2014 to June 2019. Case definition was based on an internist's review of clinopathologic data, Spec fPL concentration, and AUS findings. Information extracted from the medical records included signalment, history, physical examination findings, selected clinicopathological data (total bilirubin, glucose, ALP, ALT, and total calcium), Spec fPL concentration, AUS images/clips, length of hospitalization, and survival data. Hazard ratios were used to evaluate the association between clinicopathological data, the Spec fPL assay, AUS findings, and the length of hospitalization. Clinicopathological abnormalities, the Spec fPL, and AUS abnormalities were not statistically associated with the length of hospitalization. Despite a lack of statistical significance, the hazard ratios suggest the potential that an elevated total bilirubin (hazard ratio (HR): 1.19), hypocalcemia (HR: 1.49), and an elevated Spec fPL concentration (HR: 1.54) could be associated with prolonged hospitalization, although additional studies would be needed to verify this. Additionally, hazard ratios suggest that AUS evidence of concurrent gallbladder (HR: 1.61) and gastric abnormalities (HR: 1.36) could be associated with prolonged hospitalization.

摘要

目前用于预测猫胰腺炎严重程度的数据有限。在这个回顾性病例系列中,我们回顾了2014年6月至2019年6月期间45只患有自发性胰腺炎(SP)猫的病历。病例定义基于内科医生对临床病理数据、特异性脂肪酶(Spec fPL)浓度和腹部超声(AUS)检查结果的评估。从病历中提取的信息包括特征、病史、体格检查结果、选定的临床病理数据(总胆红素、葡萄糖、碱性磷酸酶、谷丙转氨酶和总钙)、Spec fPL浓度、AUS图像/片段、住院时间和生存数据。风险比用于评估临床病理数据(the Spec fPL检测、AUS检查结果与住院时间之间的关联。临床病理异常、Spec fPL和AUS异常与住院时间无统计学关联。尽管缺乏统计学意义,但风险比表明总胆红素升高(风险比(HR):1.19)、低钙血症(HR:1.49)和Spec fPL浓度升高(HR:1.54)可能与住院时间延长有关,不过还需要更多研究来证实这一点。此外,风险比表明AUS显示的并发胆囊异常(HR:1.61)和胃部异常(HR:1.36)可能与住院时间延长有关。

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