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模拟失重期间颅内外灌注转移:一项随机交叉试验的结果

External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial.

作者信息

Boschert Alessa L, Gauger Peter, Bach Anja, Gerlach Darius, Johannes Bernd, Jordan Jens, Li Zhili, Elmenhorst David, Bauer Andreas, Marshall-Goebel Karina, Tank Jens, Zange Jochen, Rittweger Jörn

机构信息

Department of Muscle and Bone Metabolism, German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.

Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.

出版信息

NPJ Microgravity. 2023 Mar 28;9(1):25. doi: 10.1038/s41526-023-00267-2.

DOI:10.1038/s41526-023-00267-2
PMID:36977696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10050182/
Abstract

The exact pathophysiology of the spaceflight-associated neuro-ocular syndrome (SANS) has so far not been completely elucidated. In this study we assessed the effect of acute head-down tilt position on the mean flow of the intra- and extracranial vessels. Our results suggest a shift from the external to the internal system that might play an important role in the pathomechanism of SANS.

摘要

迄今为止,太空飞行相关神经眼科综合征(SANS)的确切病理生理学尚未完全阐明。在本研究中,我们评估了急性头低位对颅内和颅外血管平均血流的影响。我们的结果表明,血流从外部系统向内部系统的转变可能在SANS的发病机制中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e7/10050182/a341eae1fb08/41526_2023_267_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e7/10050182/a341eae1fb08/41526_2023_267_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e7/10050182/a341eae1fb08/41526_2023_267_Fig1_HTML.jpg

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External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial.模拟失重期间颅内外灌注转移:一项随机交叉试验的结果
NPJ Microgravity. 2023 Mar 28;9(1):25. doi: 10.1038/s41526-023-00267-2.
2
Gravitational effects on intraocular pressure and ocular perfusion pressure.重力对眼压和眼灌注压的影响。
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本文引用的文献

1
Comparison of Dural Venous Sinus Volumes Before and After Flight in Astronauts With and Without Spaceflight-Associated Neuro-Ocular Syndrome.航天员飞行前后有/无航天相关神经眼综合征的硬脑膜静脉窦容积比较。
JAMA Netw Open. 2021 Oct 1;4(10):e2131465. doi: 10.1001/jamanetworkopen.2021.31465.
2
Effect of jump exercise training on long-term head-down bed rest-induced cerebral blood flow responses in arteries and veins.跳跃运动训练对长期头低位卧床休息引起的动静脉脑血流反应的影响。
Exp Physiol. 2021 Jul;106(7):1549-1558. doi: 10.1113/EP089102. Epub 2021 May 3.
3
Head-Down Tilt Bed Rest Studies as a Terrestrial Analog for Spaceflight Associated Neuro-Ocular Syndrome.
头低位卧床休息研究作为航天相关神经-眼综合征的地面模拟实验
Front Neurol. 2021 Mar 26;12:648958. doi: 10.3389/fneur.2021.648958. eCollection 2021.
4
Altered cerebral perfusion in response to chronic mild hypercapnia and head-down tilt Bed rest as an analog for Spaceflight.慢性轻度高碳酸血症和头低位卧床休息对脑灌注的影响 作为航天飞行的模拟。
Neuroradiology. 2021 Aug;63(8):1271-1281. doi: 10.1007/s00234-021-02660-8. Epub 2021 Feb 15.
5
Quantification of arterial, venous, and cerebrospinal fluid flow dynamics by magnetic resonance imaging under simulated micro-gravity conditions: a prospective cohort study.模拟微重力条件下磁共振成像对动脉、静脉和脑脊液流动动力学的定量分析:一项前瞻性队列研究。
Fluids Barriers CNS. 2021 Feb 12;18(1):8. doi: 10.1186/s12987-021-00238-3.
6
Intracranial Effects of Microgravity: A Prospective Longitudinal MRI Study.颅内微重力效应:一项前瞻性纵向 MRI 研究。
Radiology. 2020 Jun;295(3):640-648. doi: 10.1148/radiol.2020191413. Epub 2020 Apr 14.
7
Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update.航天相关神经眼科综合征(SANS)及微重力对神经眼科的影响:综述与更新
NPJ Microgravity. 2020 Feb 7;6:7. doi: 10.1038/s41526-020-0097-9. eCollection 2020.
8
Arterial and venous cerebral blood flow responses to long-term head-down bed rest in male volunteers.男性志愿者长期卧床头低位时的脑动脉和静脉血流反应。
Exp Physiol. 2020 Jan;105(1):44-52. doi: 10.1113/EP088057. Epub 2019 Nov 28.
9
An overview of spaceflight-associated neuro-ocular syndrome (SANS).航天相关神经眼综合征(SANS)概述。
Neurol India. 2019 May-Jun;67(Supplement):S206-S211. doi: 10.4103/0028-3886.259126.
10
Sleep Is Compromised in -12° Head Down Tilt Position.睡眠在头向下倾斜12°的姿势下受到影响。
Front Physiol. 2019 Apr 16;10:397. doi: 10.3389/fphys.2019.00397. eCollection 2019.