Olmeda Kiara, Trautner Barbara W, Laytner Lindsey, Salinas Juanita, Marton Stephanie, Grigoryan Larissa
Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX 77098, USA.
Department of Medicine, Section of Health Services Research, Baylor College of Medicine, Houston, TX 77030, USA.
Antibiotics (Basel). 2023 Mar 1;12(3):491. doi: 10.3390/antibiotics12030491.
Non-prescription antibiotic use (using antibiotics without clinical guidance) increases the risk of the development of antibiotic resistance, adverse drug reactions, and other potential patient harm. Few studies have explored non-prescription use in children in the U.S. From January 2021 to April 2022, a diverse sample of caregivers of children under 18 years were surveyed in English and Spanish at two safety net clinics in Texas. We assessed the prevalence of antibiotic use in children in the previous 12 months, storage of antimicrobials, and intended use of non-prescription antibiotics (professed intention for future non-prescription antibiotic use). We also measured sociodemographic factors, types of antibiotics used, and symptoms that trigger non-prescription use. The response rate was 82%, and 17% were surveyed in Spanish. Of 322 participants surveyed, three Spanish-speaking caregivers reported giving non-prescription antibiotics to their child in the previous 12 months. Approximately 21% ( = 69) reported storing antimicrobials at home, specifically amoxicillin ( = 52), clindamycin ( = 10), cephalexin (), penicillin ( = 3), and trimethoprim/sulfamethoxazole (). Nearly 15% ( = 46) reported intention to give non-prescription antibiotics to their children. Younger caregiver age was associated with storage and intended use of non-prescription antibiotics. Our findings will guide the development of an educational intervention to decrease non-prescription antibiotic use.
非处方抗生素的使用（即在没有临床指导的情况下使用抗生素）会增加产生抗生素耐药性、药物不良反应以及其他潜在患者伤害的风险。很少有研究探讨美国儿童的非处方抗生素使用情况。在2021年1月至2022年4月期间，我们在得克萨斯州的两家安全网诊所，用英语和西班牙语对18岁以下儿童的各类看护人进行了调查。我们评估了过去12个月儿童使用抗生素的情况、抗菌药物的储存情况以及非处方抗生素的预期使用情况（未来使用非处方抗生素的宣称意图）。我们还测量了社会人口学因素、使用的抗生素类型以及引发非处方使用的症状。回复率为82%，其中17%是用西班牙语进行调查的。在接受调查的322名参与者中，有3名讲西班牙语的看护人报告在过去12个月里给孩子使用过非处方抗生素。约21%（n = 69）报告家中储存有抗菌药物，具体为阿莫西林（n = 5）、克林霉素（n = 10）、头孢氨苄（n）、青霉素（n = 3）以及甲氧苄啶/磺胺甲恶唑（n）。近15%（n = 46）报告有给孩子使用非处方抗生素的意图。看护人年龄较小与非处方抗生素的储存和预期使用有关。我们的研究结果将指导制定一项教育干预措施，以减少非处方抗生素的使用。
