Shen Su-Chin, Chen Kuan-Jen
Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Antibiotics (Basel). 2023 Mar 18;12(3):607. doi: 10.3390/antibiotics12030607.
species are Gram-negative coccobacilli that typically colonize the flora of the human upper respiratory tract and have low pathogenic potential. There are limited case reports implicating the organisms as the cause of endocarditis, bacteremia, septic arthritis, ocular infection, and meningitis. In cases of keratitis and conjunctivitis, is not commonly isolated from the ocular surface. We present a case of a diabetic patient who developed late-onset bleb-related endophthalmitis caused by 4 years after glaucoma filtering surgery. Within one day, the patient presented with an acutely fulminant course with sudden visual loss, redness, and ocular pain. Appropriate antibiotic treatment and early vitrectomy resulted in a favorable final visual acuity of 20/100, which was his vision prior to infection. The use of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass spectrometry (MALDI-TOF MS) enabled the rapid identification of the organism. Endophthalmitis caused by should be considered in patients who underwent glaucoma filtering surgery with antifibrotic agents.
该菌种为革兰氏阴性球杆菌，通常定殖于人类上呼吸道菌群，致病潜力较低。仅有有限的病例报告表明该菌可导致心内膜炎、菌血症、化脓性关节炎、眼部感染和脑膜炎。在角膜炎和结膜炎病例中，该菌通常不会从眼表分离出来。我们报告一例糖尿病患者，在青光眼滤过手术后4年发生了由该菌引起的迟发性与滤泡相关的眼内炎。在一天之内，患者呈现出急性暴发性病程，突然视力丧失、眼红和眼痛。适当的抗生素治疗和早期玻璃体切除术使最终视力达到了20/100，这是他感染前的视力。使用基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）能够快速鉴定该菌。对于接受了抗纤维化药物青光眼滤过手术的患者，应考虑由该菌引起的眼内炎。
