Szmyd Joanna K, Lewczuk Karol, Teopiz Kayla M, McIntyre Roger S, Wichniak Adam
Third Department of Psychiatry, Institute of Psychiatry and Neurology, Jana III Sobieskiego 9, 02-957 Warsaw, Poland.
Institute of Psychology, Cardinal Stefan Wyszynski University, Dewajtis 5, 01-815 Warsaw, Poland.
Brain Sci. 2023 Feb 24;13(3):389. doi: 10.3390/brainsci13030389.
This pilot study aimed to assess patients' cognitive functioning with the Polish version of the THINC-it tool and to analyze its association with self-reported quality of life (QOL).
Twenty-one patients (mean age: 37.8 ± 10.4) were assessed at baseline and after six weeks of a standard therapeutic outpatient program. Participants completed the World Health Organization QOL Questionnaire (WHOQOL-BREF) and the THINC-it tool at both visits. The tool consists of tasks evaluating working memory (SYMBOL CHECK), attention (SPOTTER), executive functions (TRIALS), and cognitive skills (CODEBREAKER).
During the second visit, patients showed significant improvements in mean latency of correct responses of SPOTTER: = 0.021, Cohen's d = 0.38 and in the Physical health domain: = 0.007, Cohen's d = 0.37. The number of correct responses for CODEBREAKER was positively associated with the Physical health domain at visit 1 (r = 0.53, = 0.014) and visit 2 (r = 0.42, = 0.058). The number of correct responses at SYMBOL CHECK was positively related to QOL in the Environment domain only at visit 2 (r = 0.45, = 0.042).
These results suggest the THINC-it tool has utility as a cognitive measure in adults with schizophrenia in both clinical and research settings.
本试点研究旨在使用波兰语版的THINC-it工具评估患者的认知功能，并分析其与自我报告的生活质量（QOL）之间的关联。
对21名患者（平均年龄：37.8±10.4）在基线时以及标准门诊治疗方案六周后进行评估。参与者在两次就诊时均完成了世界卫生组织生活质量问卷（WHOQOL-BREF）和THINC-it工具。该工具包括评估工作记忆（符号检查）、注意力（观察者）、执行功能（试验）和认知技能（密码破解）的任务。
在第二次就诊时，患者在观察者正确反应的平均潜伏期方面有显著改善： = 0.021，科恩d值 = 0.38；在身体健康领域： = 0.007，科恩d值 = 0.37。密码破解的正确反应数量在第一次就诊时（r = 0.53， = 0.014）和第二次就诊时（r = 0.42， = 0.058）与身体健康领域呈正相关。符号检查的正确反应数量仅在第二次就诊时与环境领域的生活质量呈正相关（r = 0.45， = 0.042）。
这些结果表明，THINC-it工具在临床和研究环境中对精神分裂症成人患者作为一种认知测量工具具有实用性。
