Woo Young Sup, Lee Kyoung-Uk, Hahn Changtae, McIntyre Roger S, Teopiz Kayla M, Bahk Won-Myong
Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Clin Psychopharmacol Neurosci. 2024 Aug 31;22(3):458-465. doi: 10.9758/cpn.23.1135. Epub 2023 Nov 30.
: The present study was performed to investigate the validity and reliability of the Korean version of the THINC-it tool (THINC-it-K) in adult patients with major depressive disorder (MDD).
: Subjects aged 19-65 years with recurrent MDD experiencing moderate to severe major depressive episode (n = 44) were evaluated and compared to age and sex matched healthy controls (n = 44). Subjects completed the THINC-it-K which includes variants of the Identification Task (IDN) using Choice Reaction Time, One-Back Test, Digit Symbol Substitution Test, Trail Making Test-Part B, and the Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D).
: A total of 75.0% of patients with MDD exhibited cognitive performance 1 standard deviation or below. The differences in Spotter ( = 0.001), Codebreaker ( = 0.001), PDQ-5-D ( ＜ 0.001) and objective THINC-it-K composite score ( = 0.002) were significant between the two groups. Concurrent validity of the THINC-it-K based on a calculated composite score was good (r = 0.856, ＜ 0.001), and ranges for each component tests were from 0.076 (IDN) to 0.928 (PDQ-5-D).
: The THINC-it-K exhibits good reliability and validity in adults with MDD. It could be a useful tool for the measurement of cognitive deficits in persons with MDD and should be implemented in clinical practice.
本研究旨在调查成人重度抑郁症（MDD）患者中韩语版THINC-it工具（THINC-it-K）的有效性和可靠性。
对年龄在19 - 65岁、患有复发性MDD且经历中度至重度重度抑郁发作的受试者（n = 44）进行评估，并与年龄和性别匹配的健康对照者（n = 44）进行比较。受试者完成了THINC-it-K，其中包括使用选择反应时间的识别任务（IDN）变体、数字广度倒背测验、数字符号替换测验、连线测验B部分以及抑郁感知缺陷问卷-5项（PDQ-5-D）。
总共75.0%的MDD患者表现出认知表现低于1个标准差。两组之间在Spotter（= 0.001）、Codebreaker（= 0.001）、PDQ-5-D（＜0.001）和客观THINC-it-K综合评分（= 0.002）方面存在显著差异。基于计算得出的综合评分，THINC-it-K的同时效度良好（r = 0.856，＜0.001），各组成测试的范围从0.076（IDN）到0.928（PDQ-5-D）。
THINC-it-K在患有MDD的成年人中表现出良好的可靠性和有效性。它可能是测量MDD患者认知缺陷的有用工具，应在临床实践中应用。
