镰刀型纤维再探。

Department of Physics, Virginia Commonwealth University, Richmond, VA 23284, USA.

Department of Physics, Drexel University, Philadelphia, PA 19104, USA.

Biomolecules. 2023 Feb 22;13(3):413. doi: 10.3390/biom13030413.

Sickle cell disease is the consequence of a single point mutation on the surface of the β chains of the hemoglobin molecule leading to the formation of rigid polymers that disrupt circulation. It has long been established that the polymers are comprised of seven pairs of double strands that are twisted replicas of the double strands found in crystals. Here, we review several newer developments that elaborate on that simple model and provide deeper insights into the process.

镰状细胞病是血红蛋白分子β链表面单点突变的结果，导致形成刚性聚合物，破坏循环。长期以来，人们已经确定聚合物由七对双链组成，这些双链是在晶体中发现的双链的扭曲复制品。在这里，我们回顾了一些较新的发展，这些发展详细阐述了该简单模型，并深入了解了该过程。