Department of Ophthalmology, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
School of Medicine, University of Nevada, Reno, NV 89557, USA.
Biomolecules. 2023 Mar 20;13(3):562. doi: 10.3390/biom13030562.
The rising global prevalence of myopia is a growing concern for clinicians, as it predisposes patients to severe ocular pathologies including glaucoma. High myopia can be associated with clinical features that resemble glaucomatous damage, which make an accurate glaucoma diagnosis challenging, particularly among patients with normal intraocular pressures. These patients may also present with established visual field defects which can mimic glaucoma, and standard imaging technology is less useful in disease detection and monitoring due to the lack of normative data for these anatomically unique eyes. Progression over time remains the most critical factor in facilitating the detection of early glaucomatous changes, and thus careful longitudinal follow-up of high-risk myopic patients is the most important aspect of management. Here, we review our current understanding of the complex relationship between myopia and glaucoma, and the diagnostic challenges and limitations of current testing protocols including visual field, intraocular pressure, and imaging. Furthermore, we discuss the clinical findings of two highly myopic patients with suspected glaucoma.
全球近视患病率不断上升,这令临床医生越来越担忧,因为它使患者易患包括青光眼在内的严重眼部疾病。高度近视可能与类似青光眼损害的临床特征相关,这使得准确诊断青光眼具有挑战性,尤其是在眼压正常的患者中。这些患者也可能出现已确立的视野缺损,这些缺损可能类似于青光眼,而由于这些解剖结构独特的眼睛缺乏规范数据,标准成像技术在疾病检测和监测方面的作用就不那么有用了。随着时间的推移而进展仍然是促进早期青光眼变化检测的最关键因素,因此对高度近视患者进行仔细的纵向随访是管理的最重要方面。在这里,我们回顾了我们目前对近视和青光眼之间复杂关系的理解,以及当前测试方案(包括视野、眼压和成像)在诊断方面的挑战和局限性。此外,我们还讨论了两名高度近视疑似青光眼患者的临床发现。