Schmidt E, Bruch H P, Greulich M, Rothhammer A, Romen W
Chirurg. 1979 Feb;50(2):96-100.
The study is concerned with a problem which is to a great extent still surgically unsolved, namely that of the incontinent hollow organ occlusion. We report on our own experiments on animals and on physiologicofunctional studies, which reveal the suitability of the smooth muscles as an ideal material for sphincter replacements. By histologic research it became obvious that autotransplantations of smooth muscles, carried out for the first time by the Department of Surgery of the University of Würzburg, are possible without significant tissue changes. The transplant is soon supplied by vessels which sprout ubiquitously and completely permeate it so that it can take over its function as sphincter. Meanwhile, the experience gained in experiments on animals has been transferred to surgery on humans. Incontinence and incontinence of the preternatural anus were eliminated in the first operations using autologous autotransplanted sphincteroplasties.
这项研究关注的是一个在很大程度上仍未通过外科手术解决的问题，即无节制中空器官闭塞问题。我们报告了我们自己在动物身上进行的实验以及生理功能研究，这些研究揭示了平滑肌作为括约肌替代的理想材料的适用性。通过组织学研究发现，维尔茨堡大学外科首次进行的平滑肌自体移植是可行的，且不会发生明显的组织变化。移植组织很快就会被四处生长并完全渗透其中的血管供血，从而能够承担起括约肌的功能。与此同时，在动物实验中获得的经验已应用于人类手术。在首次使用自体移植括约肌成形术的手术中，异常肛门失禁问题得到了解决。
