Romen W, Schmidt E, Bruch H P, Rothhammer A
Chirurg. 1979 Jun;50(6):379-83.
Using autotransplants of an autonomous intestinal muscle segment a sphincter substitute and consequently a continent colostomy can be produced in humans and dogs. The histological study of the intestinal muscle section resected 1--28 weeks after implantation shows, in dogs, a good healing process and vascularization of the transplant muscle, which explains the clinical success. Even after many weeks only slight atrophy and fibrosis can be observed. Only a few of the intramural nerve plexuses perish. Some of the small intestine sphincters remain incontinent. The specimens show a more or less extensive hemorrhagic necrosis of the transplant with high inflammation. The reason for these complications is thought to be the mucosa glands, which were not completely removed from the vulnerable small intestine of the dog before the transplantation.
利用自主肠肌段的自体移植，可在人和犬身上制造括约肌替代物，进而实现可控性结肠造口术。对植入后1至28周切除的肠肌切片进行组织学研究发现，在犬身上，移植肌肉的愈合过程良好且有血管化，这解释了临床成功的原因。即使数周后，也仅能观察到轻微萎缩和纤维化。只有少数壁内神经丛会消失。一些小肠括约肌仍无法控制排便。标本显示移植组织或多或少存在广泛的出血性坏死并伴有高度炎症。这些并发症的原因被认为是黏膜腺体，在移植前未从犬的易损小肠中完全清除。
