Ernst H, Riebe M, Mohr U
Cancer Lett. 1986 May;31(2):181-6. doi: 10.1016/0304-3835(86)90009-1.
The carcinogenic effects of weekly subcutaneous injections of dimethylnitrosamine (NDMA: 0.05 of the LD50) and diethylstilbestrol (DES: 1.5 mg/kg body wt) or a combination of both carcinogens were studied in 64 Syrian hamsters. There was no additional tumorigenic effect on NDMA-induced liver tumours in hamsters which received DES treatment prior to NDMA treatment. In contrast to the previously reported DES effects, 72% of the DES-treated hamsters unexpectedly developed undifferentiated sarcomas around the interscapular injection site. This finding suggests a local carcinogenicity of DES, which might not be related to its hormonal effects.
研究人员对64只叙利亚仓鼠进行了研究，观察每周皮下注射二甲基亚硝胺（NDMA：LD50的0.05）、己烯雌酚（DES：1.5毫克/千克体重）或这两种致癌物的组合所产生的致癌作用。在NDMA治疗前接受DES治疗的仓鼠中，未发现对NDMA诱导的肝脏肿瘤有额外的致瘤作用。与之前报道的DES作用相反，72%接受DES治疗的仓鼠意外地在肩胛间注射部位周围长出了未分化肉瘤。这一发现表明DES具有局部致癌性，这可能与其激素作用无关。
