Zheng Yifan, Zhang Jing, Zhu Xiaohong, Wei Yuanjuan, Zhao Wuli, Si Shuyi, Li Yan
Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Biomedicines. 2023 Feb 21;11(3):647. doi: 10.3390/biomedicines11030647.
Mitochondria are the center of energy metabolism in eukaryotic cells and play a central role in the metabolism of living organisms. Mitochondrial diseases characterized by defects in oxidative phosphorylation are the most common congenital diseases. Meanwhile, mitochondrial dysfunction caused by secondary factors such as non-inherited genetic mutations can affect normal physiological functions of human cells, induce apoptosis, and lead to the development of various diseases. This paper reviewed several major factors and mechanisms that contribute to mitochondrial dysfunction and discussed the development of diseases closely related to mitochondrial dysfunction and drug treatment strategies discovered in recent years.
线粒体是真核细胞能量代谢的中心，在生物体的新陈代谢中起着核心作用。以氧化磷酸化缺陷为特征的线粒体疾病是最常见的先天性疾病。同时，由非遗传性基因突变等次要因素引起的线粒体功能障碍会影响人体细胞的正常生理功能，诱导细胞凋亡，并导致各种疾病的发生。本文综述了导致线粒体功能障碍的几个主要因素和机制，并讨论了与线粒体功能障碍密切相关的疾病的发展以及近年来发现的药物治疗策略。
