在生理条件下由麻黄碱、伪麻黄碱和麻黄叶提取物生成亚硝胺。

Production of nitrosamines from ephedrine, pseudoephedrine and extracts of Ephedra foliata under physiological conditions.

作者信息

Alwan S M, Al-Hindawi M K, Abdul-Rahman S K, Al-Sarraj S

出版信息

Cancer Lett. 1986 May;31(2):221-6. doi: 10.1016/0304-3835(86)90014-5.

Abstract

N-Nitrosoephedrine (NEP) and N-nitrosopseudoephedrine (NPEP) were synthesised at 5 degrees C using different concentrations of various acids. The reaction with acetic acid gave the highest yield (85%) of N-nitrosamine. Ephedrine and pseudoephedrine were reacted with nitrite under physiological conditions (37 degrees C, pH 1-3) to form NEP and NPEP. The yield of NEP, which is a known carcinogen, and NPEP were the highest (18.5%) at pH 2. Aqueous and alcoholic extracts of Ephedra foliata (100 g dry wt), nitrosated under physiological conditions, produced 0.77 mg and 8.3 mg, respectively, as total nitrosamines. This indicated the potential of the nitrosamine formation from the plant extracts specified.

摘要

在5摄氏度下，使用不同浓度的各种酸合成了N-亚硝基麻黄碱（NEP）和N-亚硝基伪麻黄碱（NPEP）。与乙酸反应生成的N-亚硝胺产率最高（85%）。麻黄碱和伪麻黄碱在生理条件（37摄氏度，pH值1 - 3）下与亚硝酸盐反应形成NEP和NPEP。已知的致癌物NEP和NPEP在pH值为2时产率最高（18.5%）。在生理条件下进行亚硝化处理的麻黄（100克干重）水提取物和醇提取物分别产生了0.77毫克和8.3毫克的总亚硝胺。这表明了从指定的植物提取物中形成亚硝胺的可能性。