Scaturro Dalila, Vitagliani Fabio, Signa Gabriele, Tomasello Sofia, Tumminelli Luigi Giuseppe, Picelli Alessandro, Smania Nicola, Letizia Mauro Giulia
Department of Surgical, Oncological and Stomatological Disciplines, University of Palermo, 90127 Palermo, Italy.
Faculty of Medicine and Surgery, University of Catania, 90121 Catania, Italy.
Biomedicines. 2023 Mar 14;11(3):892. doi: 10.3390/biomedicines11030892.
Fibromyalgia is a very common musculoskeletal disease. The purpose of this study is to assess, on a population of fibromyalgic patients, the clinical efficacy of antalgic mesotherapy with diclofenac and thiocolchicoside in the treatment of cervical pain reduction for improvement of the functional capacity and quality of life of these patients.
We conducted an observational study of 78 fibromyalgia patients recruited using our hospital database. Based on the different types of treatment received, the patients were divided into two groups: the treatment group (TG), who received antalgic mesotherapy with diclofenac, thiococolchicoside, and mepivacaina; and the placebo group (PG), who received mesotherapy with sodium chloride solution. Patients in both groups also received the same rehabilitation protocol of 20 sessions. The primary outcome evaluated was the extent of pain. The secondary outcomes were the functional capacity and quality of life.
Pain improved both in the treatment group (7.4 ± 1.2 vs. 5.1 ± 1.1; < 0.05) and placebo group (7.5 ± 1.4 vs. 6.1 ± 1.6; < 0.05). The treatment group, compared to the placebo group, also showed significant statistical improvements in functional capacity (NDI: 35.6 ± 5.23 vs. 19.3 ± 3.41; < 0.05) and quality of life (SF-12: 18.3 ± 4.11 vs. 33.1 ± 2.41; < 0.05).
Mesotherapy treatment with diclofenac and thiocolchicoside is a safe and effective procedure in the management of neck pain in fibromyalgia patients in the short term in terms of pain reduction, functional recovery and quality of life.
纤维肌痛是一种非常常见的肌肉骨骼疾病。本研究的目的是在纤维肌痛患者群体中评估双氯芬酸和秋水仙碱硫代糖苷的止痛中医疗法在减轻颈部疼痛、改善这些患者的功能能力和生活质量方面的临床疗效。
我们对通过医院数据库招募的78名纤维肌痛患者进行了一项观察性研究。根据接受的不同治疗类型，将患者分为两组：治疗组（TG），接受双氯芬酸、秋水仙碱硫代糖苷和甲哌卡因的止痛中医疗法；安慰剂组（PG），接受氯化钠溶液中医疗法。两组患者还接受了相同的20次康复方案。评估的主要结果是疼痛程度。次要结果是功能能力和生活质量。
治疗组（7.4±1.2对5.1±1.1；<0.05）和安慰剂组（7.5±1.4对6.1±1.6；<0.05）的疼痛均有所改善。与安慰剂组相比，治疗组在功能能力（NDI：35.6±5.23对19.3±3.41；<0.05）和生活质量（SF-12：18.3±4.11对33.1±2.41；<0.05）方面也显示出显著的统计学改善。
就减轻疼痛、功能恢复和生活质量而言，双氯芬酸和秋水仙碱硫代糖苷的中医疗法在短期内是治疗纤维肌痛患者颈部疼痛的一种安全有效的方法。
