Scaturro Dalila, Vitagliani Fabio, Tomasello Sofia, Filippetti Mirko, Picelli Alessandro, Smania Nicola, Letizia Mauro Giulia
Department of Surgical, Oncological and Stomatological Disciplines, University of Palermo, 90127 Palermo, Italy.
Faculty of Medicine and Surgery, University of Catania, 90121 Catania, Italy.
J Funct Morphol Kinesiol. 2022 Jun 20;7(2):51. doi: 10.3390/jfmk7020051.
Several studies have indicated a correlation between vitamin D deficiency and widespread chronic pain syndromes, such as fibromyalgia. During this study, the effect of supplementation with vitamin D in association with physical exercise in patients with fibromyalgia was evaluated, in terms of improvement of pain, functional capacity and quality of life, also evaluating the presence of any differences in age. A single-center, observational, comparative study was conducted in 80 fibromyalgia patients. They are randomized into 2 groups: Group A, consisting of patients ≤50 years; and group B, consisting of patients >50 years. Both received weekly supplementation with 50,000 IU cholecalciferol for 3 months in association with a rehabilitation protocol. Patients were assessed at enrollment (T0), 3 months (T1), and 6 months (T2) from the initial assessment with blood vitamin D dosage and administration of rating scales (NRS, FIQ, and SF-12). From the comparison between the two groups, we have seen that in young people, supplementation with high-dose vitamin D improves short-term musculoskeletal pain and long-term functional capacity. Conversely, musculoskeletal pain and long-term quality of life improve in the elderly. Supplementing with high doses of vitamin D in fibromyalgia patients improves the quality of life and pain in the elderly and also the functional capacity in the young.
多项研究表明维生素D缺乏与广泛的慢性疼痛综合征（如纤维肌痛）之间存在关联。在本研究中，评估了维生素D补充剂联合体育锻炼对纤维肌痛患者疼痛、功能能力和生活质量改善的效果，同时也评估了年龄方面是否存在差异。对80名纤维肌痛患者进行了一项单中心、观察性、对比研究。他们被随机分为两组：A组，由年龄≤50岁的患者组成；B组，由年龄>50岁的患者组成。两组均每周补充50,000 IU胆钙化醇，持续3个月，并配合康复方案。在入组时（T0）、初始评估后的3个月（T1）和6个月（T2），通过检测血液维生素D剂量并使用评分量表（NRS、FIQ和SF - 12）对患者进行评估。通过两组之间的比较，我们发现，在年轻人中，高剂量维生素D补充剂可改善短期肌肉骨骼疼痛和长期功能能力。相反，在老年人中，肌肉骨骼疼痛和长期生活质量得到改善。在纤维肌痛患者中补充高剂量维生素D可改善老年人的生活质量和疼痛，同时也可改善年轻人的功能能力。
