Department of Cell Biology, Charles University, Viničná 7, 128 00 Prague, Czech Republic.
Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Průmyslová 595, 252 50 Vestec u Prahy, Czech Republic.
Int J Mol Sci. 2023 Mar 7;24(6):5068. doi: 10.3390/ijms24065068.
MT1-MMP (MMP-14) is a multifunctional protease that regulates ECM degradation, activation of other proteases, and a variety of cellular processes, including migration and viability in physiological and pathological contexts. Both the localization and signal transduction capabilities of MT1-MMP are dependent on its cytoplasmic domain that constitutes the final 20 C-terminal amino acids, while the rest of the protease is extracellular. In this review, we summarize the ways in which the cytoplasmic tail is involved in regulating and enacting the functions of MT1-MMP. We also provide an overview of known interactors of the MT1-MMP cytoplasmic tail and the functional significance of these interactions, as well as further insight into the mechanisms of cellular adhesion and invasion that are regulated by the cytoplasmic tail.
MT1-MMP（MMP-14）是一种多功能蛋白酶，可调节细胞外基质的降解、其他蛋白酶的激活以及多种细胞过程，包括生理和病理环境下的迁移和存活。MT1-MMP 的定位和信号转导能力都依赖于其细胞质结构域，该结构域由最后 20 个 C 末端氨基酸组成，而其余的蛋白酶则位于细胞外。在这篇综述中，我们总结了细胞质尾巴参与调节和发挥 MT1-MMP 功能的方式。我们还概述了已知的 MT1-MMP 细胞质尾巴的相互作用物及其相互作用的功能意义，以及对细胞质尾巴调节的细胞黏附和侵袭机制的进一步深入了解。
