Department of Dentistry-Biomaterials, Research Institute for Medical Innovation, Radboud University Medical Centre, 6525 EX Nijmegen, The Netherlands.
Department of Dentistry-Orthodontics and Craniofacial Biology, Research Institute for Medical Innovation, Radboud University Medical Centre, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands.
Int J Mol Sci. 2023 Mar 7;24(6):5127. doi: 10.3390/ijms24065127.
Polyisocyanopeptide (PIC) hydrogels are proposed as promising wound dressings. These gels are thermo-sensitive, allow application as a cold liquid, and rely on gelation through body heat. It is supposed that the gel can be easily removed by reversing the gelation and washing it away with a cold irrigation solution. The impact on wound healing of the regular application and removal of PIC dressings is compared to a single application of PIC and the clinically used Tegaderm™ in murine splinted full-thickness wounds for up to 14 days. SPECT/CT analysis of In-labelled PIC gels showed that, on average, 58% of the PIC gel could be washed out of the wounds with the employed method, which is, however, heavily influenced by personal technique. Evaluation with photography and (immuno-)histology showed that wounds in which PIC dressings were regularly removed and replaced were smaller at 14 days post-injury but performed on par with the control treatment. Moreover, the encapsulation of PIC in wound tissue was less severe and occurred less often when PIC was regularly refreshed. In addition, no morphological damage related to the removal procedure was observed. Thus, PIC gels are atraumatic and perform similarly to currently employed wound dressing materials, offering possible future benefits for both clinicians and patients.
聚异氰酸肽（PIC）水凝胶被认为是很有前途的伤口敷料。这些凝胶具有温度敏感性，可以作为冷液体应用，并通过体温凝胶化。据称，通过逆转凝胶化并用冷灌洗液冲洗，可以轻松去除凝胶。将 PIC 敷料的常规应用和去除对伤口愈合的影响与 PIC 的单次应用和临床上使用的 Tegaderm™在小鼠夹板全厚度伤口中进行了长达 14 天的比较。In 标记的 PIC 凝胶的 SPECT/CT 分析表明，平均有 58%的 PIC 凝胶可以用所采用的方法从伤口中冲洗出来，但这受到个人技术的严重影响。摄影和（免疫）组织学评估表明，在受伤后 14 天，定期更换和更换 PIC 敷料的伤口较小，但与对照治疗相当。此外，当 PIC 定期更新时，PIC 在伤口组织中的包封程度较轻，发生频率也较低。此外，没有观察到与去除过程相关的形态损伤。因此，PIC 凝胶无创伤，与目前使用的伤口敷料材料性能相似，为临床医生和患者带来了未来的潜在益处。
