Guechot J, Lioret N, Cynober L, Letort C, Saizy R, Giboudeau J
Clin Chem. 1986 May;32(5):857-9.
Myoglobin is released into the blood after burn injury. We measured it and other analytes in blood collected from 22 burn patients two to seven times during their recovery. There was a significant correlation between myoglobinemia and creatine kinase (CK) activity in serum (r = 0.764; p less than 0.001). In a group of 14 thermal-burn subjects a correlation was found between burn depth (clinically expressed as Unit Burn Surface) and both myoglobinemia (r = 0.825; p less than 0.01) and CK activity (r = 0.686; p less than 0.01). In eight thermal-burn patients who were recovering satisfactorily, myoglobin and CK activity measured on days 2, 4, 7, 10, and 13 after injury were significantly increased (p less than 0.05) on days 2, 4, and 7. Evidently myoglobinemia and CK activity are good biological markers of burn depth, and reflect muscle damage equally well.
烧伤后肌红蛋白会释放入血。我们对22名烧伤患者在恢复过程中采集的血液进行了2至7次检测，测量了其中的肌红蛋白及其他分析物。血清中的肌红蛋白血症与肌酸激酶（CK）活性之间存在显著相关性（r = 0.764；p < 0.001）。在一组14名热烧伤受试者中，发现烧伤深度（临床表示为烧伤面积单位）与肌红蛋白血症（r = 0.825；p < 0.01）和CK活性（r = 0.686；p < 0.01）均存在相关性。在8名恢复情况良好的热烧伤患者中，受伤后第2、4、7、10和13天测量的肌红蛋白和CK活性在第2、4和7天显著升高（p < 0.05）。显然，肌红蛋白血症和CK活性是烧伤深度的良好生物学标志物，并且能同样良好地反映肌肉损伤情况。
