Al-Hawasi Abbas, Lagali Neil, Fagerholm Per, Huang-Link Yumin
Division of Ophthalmology, Department of Biomedical and Clinical Sciences, Faculty of Medicine, Linköping University, 581 83 Linköping, Sweden.
Division of Neurology, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.
J Clin Med. 2023 Mar 14;12(6):2240. doi: 10.3390/jcm12062240.
A benign form of multiple sclerosis (BMS) is not easily diagnosed, but changes of the retinal ganglion cell layer-inner plexiform layer (GCL-IPL) and retinal nerve fiber layer (RNFL) may be sensitive to the disease. The aim of this study was to use optical coherence tomography (OCT) to investigate longitudinal changes of GCL-IPL and RNFL in BMS. Eighteen patients with BMS and 22 healthy control (HC) subjects were included, with a mean follow-up period of 32.1 months in BMS and 34.3 months in HC. Mean disease duration in BMS was 23.3 years, with 14 patients left untreated. Unilateral optic neuritis (ON) was found in eight patients. Non-ON eyes showed thinner GCL-IPL layer in the BMS group relative to HC ( < 0.001). The thinning rate of GCL-IPL in non-ON BMS, however, was -0.19 ± 0.15 µm/year vs. 0 ± 0.11 µm/year for HC ( = 0.573, age-adjusted). Thinning rate of RNFL in non-ON BMS was -0.2 ± 0.27 µm/year vs. -0.05 ± 0.3 µm/year for HC ( = 0.454, age adjusted). Conclusions: Thinning rate of the GCL-IPL and RNFL in BMS is similar to the healthy population but differs from the thinning rate in relapsing-remitting MS, presenting a non-invasive OCT-based criterion for assessing a benign course in multiple sclerosis.
一种良性形式的多发性硬化症（BMS）不易诊断，但视网膜神经节细胞层-内网状层（GCL-IPL）和视网膜神经纤维层（RNFL）的变化可能对该疾病敏感。本研究的目的是使用光学相干断层扫描（OCT）来研究BMS中GCL-IPL和RNFL的纵向变化。纳入了18例BMS患者和22名健康对照（HC）受试者，BMS组的平均随访期为32.1个月，HC组为34.3个月。BMS的平均病程为23.3年，14例患者未接受治疗。8例患者出现单侧视神经炎（ON）。与HC组相比，BMS组非ON眼的GCL-IPL层更薄（<0.001）。然而，非ON的BMS中GCL-IPL的变薄率为-0.19±0.15 µm/年，而HC组为0±0.11 µm/年（P = 0.573，年龄校正）。非ON的BMS中RNFL的变薄率为-0.2±0.27 µm/年，而HC组为-0.05±0.3 µm/年（P = 0.454，年龄校正）。结论：BMS中GCL-IPL和RNFL的变薄率与健康人群相似，但与复发缓解型MS的变薄率不同，为评估多发性硬化症的良性病程提供了一种基于OCT的非侵入性标准。
