Keye Philip, Böhringer Daniel, Anton Alexandra, Reinhard Thomas, Lübke Jan
Eye Center, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
ADMEDICO Augenzentrum, Fährweg 10, 4600 Olten, Switzerland.
J Clin Med. 2023 Mar 14;12(6):2247. doi: 10.3390/jcm12062247.
(1) Background: Due to significant variation, sporadic IOP measurements often fail to correctly assess the IOP situation in glaucoma patients. Thus, diurnal-nocturnal IOP profiles can be used as a diagnostic tool. The purpose of this study is to determine the additional diagnostic value of prolonged IOP profiles. (2) Methods: All diagnostic 48 h IOP profiles from a large university hospital, between 2017 and 2019, were reviewed. Elevated IOP > 21 mmHg, IOP variation > 6 mmHg and nocturnal IOP peaks were defined as IOP events of interest and counted. The analysis was repeated for the first 24 h of every IOP profile only. The Chi test was used for statistical analysis. (3) Results: 661 IOP profiles were included. Specifically, 59% of the 48 h IOP profiles revealed IOP values above 21 mmHg, and 87% showed IOP fluctuation greater than 6 mmHg. Nocturnal peaks in the supine position could be observed in 51% of the patients. In the profiles censored for the first 24 h, the fractions were 50%, 71% and 48%, ( < 0.01, < 0.01 and = 0.12) respectively. (4) Conclusions: the 48 h IOP profiles identified more patients with IOP events of interest than the 24 h IOP profiles. The additional diagnostic value must be weighed against the higher costs.
(1) 背景：由于存在显著差异，偶尔进行的眼压测量往往无法正确评估青光眼患者的眼压情况。因此，昼夜眼压曲线可作为一种诊断工具。本研究的目的是确定延长眼压曲线的额外诊断价值。(2) 方法：回顾了2017年至2019年期间一家大型大学医院所有诊断性48小时眼压曲线。眼压升高>21 mmHg、眼压变化>6 mmHg和夜间眼压峰值被定义为感兴趣的眼压事件并进行计数。仅对每个眼压曲线的前24小时重复进行分析。采用卡方检验进行统计分析。(3) 结果：纳入了661条眼压曲线。具体而言，48小时眼压曲线中有59%显示眼压值高于21 mmHg，87%显示眼压波动大于6 mmHg。51%的患者可观察到仰卧位夜间峰值。在前24小时截短的曲线中，这些比例分别为50%、71%和48%（<0.01、<0.01和 = 0.12）。(4) 结论：48小时眼压曲线比24小时眼压曲线识别出更多有感兴趣眼压事件的患者。额外的诊断价值必须与更高的成本相权衡。
