及橙酮 A 的结构修订中的复杂黄烷酮。
Complex Flavanones from and Structural Revision of Oboflavanone A.
机构信息
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, People's Republic of China.
Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, People's Republic of China.
出版信息
J Nat Prod. 2022 Jun 24;85(6):1617-1625. doi: 10.1021/acs.jnatprod.2c00279. Epub 2022 May 29.
Nine new complex flavanones, cryptometcones A-I (-), along with four known analogues, were isolated from . The structures of - including their absolute configurations were elucidated by spectroscopic data analysis and electronic circular dichroism (ECD) calculations. In addition, the structure of oboflavanone A was revised, while the absolute configurations of oboflavanone B, cryptoflavanone C, and cryptoflavanone D were determined, according to their spectroscopic data. Compounds -, , and exhibited cytotoxicity against the HCT-116 cancer cell line.
从 中分离得到了 9 种新的复杂黄烷酮，cryptometcones A-I (-)，以及 4 种已知类似物。通过光谱数据分析和电子圆二色性 (ECD) 计算阐明了 - 的结构，包括它们的绝对构型。此外，根据光谱数据，修订了 oboflavanone A 的结构，确定了 oboflavanone B、cryptoflavanone C 和 cryptoflavanone D 的绝对构型。化合物 - 、- 和 - 对 HCT-116 癌细胞系具有细胞毒性。
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