Department of Ophthalmology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Love Eye Clinic, Hwaseong 18309, Republic of Korea.
Medicina (Kaunas). 2023 Mar 12;59(3):558. doi: 10.3390/medicina59030558.
: We investigated and compared the efficacy of three and five monthly loading regimens of an intravitreal aflibercept injection (IVA) in patients with diabetic macular edema (DME). : This was a retrospective study that included patients diagnosed with DME and treated with an either three or five monthly aflibercept loading regimen from July 2018 to March 2022. Information on clinical characteristics and changes in the central retinal thickness (CRT) were obtained from medical records. : In total, 44 eyes of 44 patients with DME treated with IVA were included in this study, with 30 eyes treated with 3-monthly loadings (three-loading group) and 14 eyes with 5-monthly loadings (five-loading group). The mean CRT significantly decreased from the baseline one month after loading in both the three-loading and five-loading groups ( < 0.001). Four cases were refractory to treatment in the three-loading group, while there were no cases of refractory DME in the five-loading group. The stability rate was significantly higher in the five-loading group at three months after loading ( = 0.033). : Five-monthly loading regimens of IVA might be favorable for DME considering the rate of refractory cases, stable duration, and the importance of early responsiveness to IVA in DME.
我们研究并比较了三种和五种每月负荷剂量玻璃体内注射阿柏西普（IVA）治疗糖尿病性黄斑水肿（DME）的疗效。
这是一项回顾性研究，纳入了 2018 年 7 月至 2022 年 3 月期间接受三种或五种每月阿柏西普负荷剂量治疗的 DME 患者。从病历中获取了临床特征和中心视网膜厚度（CRT）变化的信息。
本研究共纳入了 44 例 DME 患者的 44 只眼，接受 IVA 治疗，其中 30 只眼接受了三个月负荷剂量（三组），14 只眼接受了五个月负荷剂量（五组）。三组和五组在负荷后一个月 CRT 均较基线显著降低（<0.001）。三组中有 4 例治疗抵抗，而五组中无 DME 治疗抵抗病例。三组在负荷后三个月的稳定性率显著高于五组（=0.033）。
考虑到 DME 的难治病例率、稳定持续时间以及 IVA 早期反应的重要性，IVA 五种每月负荷剂量可能对 DME 更为有利。
