新设计的抗菌肽Crabrolin21的结构与功能特性

Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21.

作者信息

Cantini Francesca, Giannì Paola, Bobone Sara, Troiano Cassandra, van Ingen Hugo, Massoud Renato, Perini Nicoletta, Migliore Luciana, Savarin Philippe, Sanders Charles, Stella Lorenzo, Sette Marco

机构信息

Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino, 50019 Firenze, Italy.

Department of Chemistry, University of Florence, Sesto Fiorentino, 50019 Firenze, Italy.

出版信息

Membranes (Basel). 2023 Mar 22;13(3):365. doi: 10.3390/membranes13030365.

DOI:10.3390/membranes13030365

PMID:36984752

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10053045/

Abstract

(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and structural properties with a wide range of techniques. (3) Results: the newly designed peptide, crabrolin21, is much more active than the previous ones and shows specific selectivity towards bacterial cells. (4) Conclusions: crabrolin21 shows interesting properties and deserves further studies.

摘要

(1) 背景：抗菌药物耐药性正成为公共卫生领域的一个严峻问题，新型抗菌药物的设计是一个活跃的研究领域。(2) 方法：基于我们之前的工作，我们设计了一种改良版的克拉布罗林肽，并运用多种技术对其功能和结构特性进行了表征。(3) 结果：新设计的肽，即克拉布罗林21，比之前的肽活性更强，且对细菌细胞表现出特异性选择性。(4) 结论：克拉布罗林21展现出有趣的特性，值得进一步研究。