Yahoum Madiha Melha, Toumi Selma, Tahraoui Hichem, Lefnaoui Sonia, Kebir Mohammed, Amrane Abdeltif, Assadi Aymen Amin, Zhang Jie, Mouni Lotfi
Materials and Environmental Laboratory (LME), University of Medea, Nouveau Pole Urbain, Medea 26000, Algeria.
Faculty of Sciences, University of Medea, Nouveau Pole Urbain, Medea 26000, Algeria.
Micromachines (Basel). 2023 Mar 6;14(3):609. doi: 10.3390/mi14030609.
This work aimed to formulate xanthan gum microspheres for the encapsulation of metformin hydrochloride, according to the process of ionotropic gelation. The obtained microparticles, based on various fractions of xanthan gum (0.5-1.25), were subjected to different physico-chemical tests and a drug release study. Microspheres with an average size varying between 110.96 μm and 208.27 μm were obtained. Encapsulation efficiency reached 93.11% at a 1.25% biopolymer concentration. The swelling study showed a swelling rate reaching 29.8% in the gastric medium (pH 1.2) and 360% in the intestinal medium (pH 6.8). The drug release studies showed complete metformin hydrochloride release from the beads, especially those prepared from xanthan gum at the concentration of 1.25%, in intestinal medium at 90.00% after 6 h. However, limited and insignificant drug release was observed within the gastric medium (32.50%). The dissolution profiles showed sustained release kinetics.
本研究旨在根据离子凝胶化过程制备用于包封盐酸二甲双胍的黄原胶微球。基于不同比例的黄原胶（0.5 - 1.25）制备得到的微粒，进行了不同的理化测试和药物释放研究。获得了平均尺寸在110.96μm至208.27μm之间的微球。在生物聚合物浓度为1.25%时，包封效率达到93.11%。溶胀研究表明，在胃介质（pH 1.2）中的溶胀率达到29.8%，在肠介质（pH 6.8）中达到360%。药物释放研究表明，盐酸二甲双胍从微球中完全释放，尤其是由浓度为1.25%的黄原胶制备的微球，在肠介质中6小时后释放率为90.00%。然而，在胃介质中观察到药物释放有限且不显著（32.50%）。溶出曲线显示为缓释动力学。
