Centre for Radiation and Environmental Science, FOCAS Research Institute, Technological University Dublin-City Campus, D02 HW71 Dublin, Ireland.
School of Physics, Clinical and Optometric Sciences, Central Quad, Technological University Dublin-City Campus, D07 XT95 Dublin, Ireland.
Molecules. 2023 Mar 9;28(6):2502. doi: 10.3390/molecules28062502.
This review focuses on recent advances and future perspectives in the use of Raman spectroscopy for cervical cancer, a global women's health issue. Cervical cancer is the fourth most common women's cancer in the world, and unfortunately mainly affects younger women. However, when detected at the early precancer stage, it is highly treatable. High-quality cervical screening programmes and the introduction of the human papillomavirus (HPV) vaccine are reducing the incidence of cervical cancer in many countries, but screening is still essential for all women. Current gold standard methods include HPV testing and cytology for screening, followed by colposcopy and histopathology for diagnosis. However, these methods are limited in terms of sensitivity/specificity, cost, and time. New methods are required to aid clinicians in the early detection of cervical precancer. Over the past 20 years, the potential of Raman spectroscopy together with multivariate statistical analysis has been shown for the detection of cervical cancer. This review discusses the research to date on Raman spectroscopic approaches for cervical cancer using exfoliated cells, biofluid samples, and tissue ex vivo and in vivo.
本文重点介绍了拉曼光谱技术在宫颈癌研究中的最新进展和未来展望，宫颈癌是全球女性健康的一大问题。宫颈癌是全球第四大常见的女性癌症，不幸的是，主要影响年轻女性。然而，当在癌前早期阶段被发现时，它是高度可治疗的。高质量的宫颈癌筛查计划和人乳头瘤病毒（HPV）疫苗的引入降低了许多国家宫颈癌的发病率，但对所有女性来说，筛查仍然是必要的。目前的金标准方法包括 HPV 检测和细胞学筛查，然后是阴道镜检查和组织病理学诊断。然而，这些方法在灵敏度/特异性、成本和时间方面存在局限性。需要新的方法来帮助临床医生早期发现宫颈癌前病变。在过去的 20 年中，拉曼光谱技术结合多元统计分析已经显示出在宫颈癌检测方面的潜力。本文讨论了迄今为止使用脱落细胞、生物流体样本以及组织离体和在体的拉曼光谱方法在宫颈癌研究中的应用。
