Research Centre, CHU Sainte-Justine, 3175 Sainte-Catherine Road, Montreal, QC H3T 1C5, Canada.
Department of Nutrition, Université de Montreal, C. P. 6205, succursale Centre-ville, Montreal, QC H3C 3T5, Canada.
Nutrients. 2023 Mar 14;15(6):1394. doi: 10.3390/nu15061394.
Milk-derived bioactive proteins have increasingly gained attention and consideration throughout the world due to their high-quality amino acids and multiple health-promoting attributes. Apparently, being at the forefront of functional foods, these bioactive proteins are also suggested as potential alternatives for the management of various complex diseases. In this review, we will focus on lactoferrin (LF) and osteopontin (OPN), two multifunctional dairy proteins, as well as to their naturally occurring bioactive LF-OPN complex. While describing their wide variety of physiological, biochemical, and nutritional functionalities, we will emphasize their specific roles in the perinatal period. Afterwards, we will evaluate their ability to control oxidative stress, inflammation, gut mucosal barrier, and intestinal microbiota in link with cardiometabolic disorders (CMD) (obesity, insulin resistance, dyslipidemia, and hypertension) and associated complications (diabetes and atherosclerosis). This review will not only attempt to highlight the mechanisms of action, but it will critically discuss the potential therapeutic applications of the underlined bioactive proteins in CMD.
由于其高质量的氨基酸和多种促进健康的特性，乳源生物活性蛋白在全球范围内越来越受到关注和重视。显然，作为功能性食品的前沿，这些生物活性蛋白也被认为是管理各种复杂疾病的潜在替代品。在这篇综述中，我们将重点介绍乳铁蛋白 (LF) 和骨桥蛋白 (OPN) 这两种多功能乳制品蛋白，以及它们天然存在的生物活性 LF-OPN 复合物。在描述它们广泛的生理、生化和营养功能的同时，我们将强调它们在围产期的特定作用。之后，我们将评估它们控制氧化应激、炎症、肠道黏膜屏障和肠道微生物群与心血管代谢紊乱（CMD）（肥胖、胰岛素抵抗、血脂异常和高血压）及其相关并发症（糖尿病和动脉粥样硬化）的能力。本综述不仅试图强调作用机制，还将批判性地讨论潜在的治疗应用的生物活性蛋白在 CMD。
