Jara Luis M, Angulo-Tisoc Jose, Giménez-Lirola Luis G, Li Ganwu, Andrade Roy, Mamani Javier
Facultad de Medicina Veterinaria y Zootecnia, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.
Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima 15021, Peru.
Pathogens. 2023 Mar 12;12(3):445. doi: 10.3390/pathogens12030445.
is an emerging zoonotic pathogen involved in septicemic infections in humans and livestock. Raising guinea pigs in South America is an important economic activity compared to raising them as pets in other countries. An outbreak of severe lymphadenitis was reported in guinea pigs from farms in the Andean region. was isolated from multiple cervical and mandibular abscesses. Isolate was characterized by multilocus sequence typing and phylogenetic analysis. This is the first molecular characterization of a highly pathogenic strain, showing major important virulence factors such as the M-like protein genes and , the fimbrial subunit protein gene , and the protective antigen-like protein gene Additionally, this guinea pig strain was phylogenetically related to equines but distant from zoonotic and pig isolates reported in other countries.
是一种新兴的人畜共患病原体，可导致人类和牲畜的败血症感染。与在其他国家作为宠物饲养豚鼠相比，在南美洲饲养豚鼠是一项重要的经济活动。据报道，安第斯地区农场的豚鼠爆发了严重的淋巴结炎。从多个颈部和下颌脓肿中分离出了（病原体）。分离株通过多位点序列分型和系统发育分析进行了表征。这是高致病性菌株的首次分子表征，显示出主要的重要毒力因子，如M样蛋白基因和，菌毛亚基蛋白基因，以及保护性抗原样蛋白基因。此外，这种豚鼠菌株在系统发育上与马相关，但与其他国家报道的人畜共患病和猪分离株距离较远。
