N Hlengwa, C Masilela, T R Mtambo, S Sithole, S Naidoo, K E Machaba, S C Shabalala, Y Ntamo, P V Dludla, R N Milase
Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa.
Department of Biochemistry, North-West University, Mafikeng 2745, South Africa.
Pharmaceuticals (Basel). 2023 Mar 8;16(3):409. doi: 10.3390/ph16030409.
A newfound appreciation for the benefits of herbal treatments has emerged in recent decades. However, herbal medication production still needs to establish standardized protocols that adhere to strict guidelines for quality assurance and risk minimization. Although the therapeutic effects of herbal medicines are extensive, the risk of herb-drug interactions remains a serious concern, limiting their use. Therefore, a robust, well-established liver model that can fully represent the liver tissue is required to study potential herb-drug interactions to ensure herbal medicines' safe and effective use. In light of this, this mini review investigates the existing liver models applicable to detecting herbal medicines' toxicity and other pharmacological targets. This article analyzes the benefits and drawbacks of existing liver cell models. To maintain relevance and effectively express the offered research, a systematic strategy was employed to search for and include all discussed studies. In brief, from 1985 to December 2022, the phrases "liver models", "herb-drug interaction", "herbal medicine", "cytochrome P450", "drug transporters pharmacokinetics", and "pharmacodynamics" were combined to search the electronic databases PubMed, ScienceDirect, and the Cochrane Library.
近几十年来，人们对草药治疗的益处有了新的认识。然而，草药制剂的生产仍需建立标准化方案，以遵循严格的质量保证和风险最小化指南。尽管草药的治疗作用广泛，但草药与药物相互作用的风险仍然是一个严重问题，限制了它们的使用。因此，需要一个能够充分代表肝脏组织的强大、成熟的肝脏模型来研究潜在的草药与药物相互作用，以确保草药的安全有效使用。有鉴于此，本综述探讨了适用于检测草药毒性和其他药理学靶点的现有肝脏模型。本文分析了现有肝细胞模型的优缺点。为了保持相关性并有效表达所提供的研究内容，我们采用了一种系统策略来搜索并纳入所有讨论过的研究。简而言之，从1985年到2022年12月，我们将“肝脏模型”“草药与药物相互作用”“草药”“细胞色素P450”“药物转运体、药代动力学”和“药效学”等短语组合起来，搜索电子数据库PubMed、ScienceDirect和Cochrane图书馆。
