Kaur Boparai Anoop, Jain Ashish, Arora Suraj, Abullais Saquib Shahabe, Abdullah Alqahtani Nabeeh, Fadul A Elagib Mohamed, Grover Vishakha
Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, India.
Department of Periodontology & Oral Implantology, Dr. H. S. J. lnstitute Dental Sciences & Hospital, Punjab University, Chandigarh, India.
J King Saud Univ Sci. 2023 May;35(4):102646. doi: 10.1016/j.jksus.2023.102646. Epub 2023 Mar 18.
The most grievous threat to human health has been witnessed worldwide with the recent outbreak of Corona virus disease 2019 (COVID-19). There is mounting evidence available regarding theconnect of COVID -19 and oral cavity, particularly periodontal disease. The current review provides an update on the diagnostic potential of dental calculus and how this bio resource may help in providing us huge amount of diagnostic regarding the causative virus. Contemporary standard method of diagnosis via nasopharyngeal swabs (NPS) is tedious, may enhance the risk of aerosol contamination by inducing sneezing and detects the presence of active infection only.However,dental calculus being a mineralized deposit serves as a reservoir for biomoleculesand provides detection of past SARS CoV2 infection. Further, the abundance of information that can be obtained from this remarkable mineralized deposit on teeth regarding the viral genome, its evolution and interactions with the oral microflora shall enhance the understanding of the viral disease process and its connection with the periodontal disease. Additional diagnostic information, which may be obtained from this simple bio reservoir can complement the contemporary diagnostic strategies adopted in the management of COVID-19pandemic and enhance our existing knowledge for developing improvised novel approaches to mitigate the effects of mutated variants of the infectious agent.
随着2019年冠状病毒病（COVID-19）近期在全球范围内的爆发，人类健康面临着最严重的威胁。关于COVID-19与口腔尤其是牙周疾病之间的联系，现有越来越多的证据。本综述提供了关于牙结石诊断潜力的最新信息，以及这种生物资源如何有助于为我们提供大量有关致病病毒的诊断信息。目前通过鼻咽拭子（NPS）进行诊断的标准方法繁琐，可能会因诱发打喷嚏而增加气溶胶污染的风险，并且只能检测到活动性感染的存在。然而，牙结石作为一种矿化沉积物，可作为生物分子的储存库，并能检测出过去的SARS-CoV-2感染。此外，从牙齿上这种非凡的矿化沉积物中可以获得的关于病毒基因组、其进化以及与口腔微生物群相互作用的大量信息，将加深对病毒疾病过程及其与牙周疾病联系的理解。从这个简单的生物储存库中可能获得的额外诊断信息，可以补充COVID-19大流行管理中采用的当代诊断策略，并增强我们现有的知识，以开发改进的新方法来减轻感染病原体变异株的影响。
