Connor M C, Copeland M, Curran T
Regional Virus Laboratory, Royal Vitoria Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
Mater Infirmorum Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
J Clin Virol. 2022 Jan;146:105053. doi: 10.1016/j.jcv.2021.105053. Epub 2021 Dec 10.
Throughout the ongoing SARS-CoV-2 pandemic, the recommended sample type for initial diagnostic testing for SARS-CoV-2 infection has been a nasopharyngeal swab. Shortages in swabs and difficulties in obtaining nasopharyngeal swabs in certain patient groups has prompted research into alternative specimen types for the diagnosis of COVID-19. The aim of this study was to assess how 'simply collected' saliva along with tongue swabs and buccal swabs preformed as an alternative specimen type for SARS-CoV-2 detection. It was observed that saliva samples allowed for the detection of 85.3% of positive patients, tongue swabs allowed for the detection of 67.6% of positive patients and buccal swabs allowed for detection of 20.8% of positive patients, when compared to nasopharyngeal swabs. From this data, it could be concluded that using simple saliva collection can provide a less invasive and reliable alternative method for the detection of SARS-CoV2 particularly in those patients where invasive sampling is difficult and where regular repeat testing is required.
在持续的新冠疫情期间，用于新冠病毒感染初始诊断检测的推荐样本类型一直是鼻咽拭子。拭子短缺以及在某些患者群体中获取鼻咽拭子存在困难，促使人们对用于诊断新冠的替代样本类型展开研究。本研究的目的是评估“简单采集”的唾液以及舌拭子和颊拭子作为新冠病毒检测的替代样本类型的表现。结果发现，与鼻咽拭子相比，唾液样本能检测出85.3%的阳性患者，舌拭子能检测出67.6%的阳性患者，颊拭子能检测出20.8%的阳性患者。根据这些数据可以得出结论，使用简单的唾液采集可为新冠病毒检测提供一种侵入性较小且可靠的替代方法，尤其是在那些难以进行侵入性采样且需要定期重复检测的患者中。
