Mancini Leonardo, Americo Lorenzo Maria, Pizzolante Tommaso, Donati Raffaele, Marchetti Enrico
Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
PerioAQ Group, Clinica Odontoiatrica Delta Sei, L'Aquila, Italy.
Front Oral Health. 2022 Feb 10;3:822824. doi: 10.3389/froh.2022.822824. eCollection 2022.
COVID-19 is reported as one of the most widespread diseases in the world. An extraordinary number of articles and manuscripts have focused on the inflammatory cascade and sequelae, showing the important roles of cytokines and renin-angiotensin levels and possible links to other pathologies. Nowadays, interest regarding the possible correlation between COVID-19 and periodontal and Peri-implant diseases is increasing. This mini-review aims to collect data regarding the possible correlation between COVID-19 and periodontitis or Peri-implantitis through the analysis of articles published in the last 3 years. The following keywords were used: ([periodontitis OR periodontal disease] AND [COVID-19]); ([Peri-implantitis OR mucositis] AND [COVID-19 OR Sars-CoV-2]). The inclusion criteria were studies on COVID-19 or SARS-CoV-2 and periodontitis or Peri-implantitis, and studies on the molecular and cellular aspect of COVID-19 in periodontal or Peri-implant tissues. The search revealed 484 articles in total (PubMed 208 and Scopus 276). After a screening of titles and abstracts, 47 articles were included in the full-text analysis. Two articles comprised the Peri-implant group: a short communication and a review. Regarding the periodontal group, 45 articles were selected and analyzed according to the type of study, population, and aim. Of these, 10 articles were clinical studies, and the other 35 were hypotheses, reviews, letters to the editor, or commentaries. In conclusion, according to the data extracted, a mutual correlation between COVID-19 and periodontitis can be stated; however, data linked to Peri-implantitis are still missing, and future clinical studies are still needed.
据报道，新型冠状病毒肺炎（COVID-19）是世界上传播最广泛的疾病之一。大量的文章和手稿都聚焦于炎症级联反应和后遗症，揭示了细胞因子和肾素-血管紧张素水平的重要作用以及与其他病理状况的可能联系。如今，人们对COVID-19与牙周病和种植体周围疾病之间可能存在的相关性的关注度日益增加。这篇小型综述旨在通过分析过去3年发表的文章，收集有关COVID-19与牙周炎或种植体周围炎之间可能存在的相关性的数据。使用了以下关键词：（[牙周炎或牙周疾病] AND [COVID-19]）；（[种植体周围炎或黏膜炎] AND [COVID-19或严重急性呼吸综合征冠状病毒2（Sars-CoV-2）]）。纳入标准为关于COVID-19或Sars-CoV-2以及牙周炎或种植体周围炎的研究，以及关于COVID-19在牙周或种植体周围组织中的分子和细胞方面的研究。检索总共发现484篇文章（PubMed数据库208篇，Scopus数据库276篇）。在对标题和摘要进行筛选后，47篇文章被纳入全文分析。两篇文章属于种植体周围组：一篇简短通讯和一篇综述。关于牙周组，根据研究类型、人群和目的选择并分析了45篇文章。其中，10篇为临床研究，另外35篇为假说、综述、给编辑的信或评论。总之，根据提取的数据，可以表明COVID-19与牙周炎之间存在相互关联；然而，与种植体周围炎相关的数据仍然缺失，未来仍需要进行临床研究。
