Department of Chemical Engineering, University of New Hampshire, Durham, NH 03824, USA.
J Mater Chem B. 2023 Apr 12;11(15):3356-3363. doi: 10.1039/d3tb00312d.
Herein, we present the facile synthesis of poly(pyrogallol) biopolymers and their application as antibacterial agents. Pyrogallol is a class of phenolic compounds that can be found in various plants. Polymerization was performed by the auto-oxidation of pyrogallol under a hydrated condition. The microscopic image of poly(pyrogallol) shows a highly homogenous nanofibrous structure with a diameter of 100.3 ± 16.3 nm. Spectroscopic analysis by FT-IR spectroscopy, Raman spectroscopy, and XPS corroborated the formation of ether (C-O-C) bonds between the hydroxyl group and adjacent carbons of pyrogallol during polymerization. The FT-IR and XPS spectra also revealed redox-active gallol functional groups on poly(pyrogallol) nanofibers, which can be used to release free electrons and protons during oxidation followed by the generation of reactive oxygen species (ROS). The generated ROS from poly(pyrogallol) was used to inhibit the growth of bacteria, , at a inhibition rates of 56.3 ± 9.7% and 95.5 ± 2.0% within 0.5 and 2 h, respectively. This finding suggests that poly(pyrogallol) can be used as a naturally occurring antibacterial agent for various biomedical and environmental applications.
本文介绍了聚（没食子酸）生物聚合物的简便合成及其作为抗菌剂的应用。没食子酚是一类存在于多种植物中的酚类化合物。聚合反应是通过水合条件下没食子酚的自动氧化来进行的。聚（没食子酸）的微观图像显示出高度均匀的纳米纤维结构，直径为 100.3 ± 16.3nm。傅里叶变换红外光谱（FT-IR）、拉曼光谱和 X 光电子能谱（XPS）的光谱分析证实了聚合过程中羟基和相邻没食子酚碳原子之间形成了醚（C-O-C）键。FT-IR 和 XPS 光谱还揭示了聚（没食子酸）纳米纤维上的氧化还原活性邻苯三酚官能团，这些官能团在氧化过程中可以释放自由电子和质子，从而产生活性氧物种（ROS）。聚（没食子酸）产生的 ROS 用于抑制细菌的生长，在 0.5 和 2 小时内，对细菌的抑制率分别为 56.3 ± 9.7%和 95.5 ± 2.0%。这一发现表明，聚（没食子酸）可以用作各种生物医学和环境应用的天然抗菌剂。
