College of Chemistry and Molecular Sciences, Hubei Engineering Center of Natural Polymer-based Medical Materials, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan 430072, China.
Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Carbohydr Polym. 2022 Aug 15;290:119444. doi: 10.1016/j.carbpol.2022.119444. Epub 2022 Apr 2.
The metal-polyphenol networks have attracted appealing attention for diverse biomedical applications due to their remarkable characteristics. Though various of metal-polyphenolic materials have been prepared, the homogeneous metal-polyphenol based hydrogel fabrication remains a challenge (e.g., quick aggregation). Herein, a facile and low-cost polyphenol-mediating non-covalent driven assembly strategy was developed for fabricating homogeneous chitin-polyphenol-metal hydrogels. Polyphenols not only noncovalently crosslinked chitin chains, but simultaneously captured metal nanomaterials from metal substrates and immobilized in chitin-polyphenol networks. A range of metal (Fe, Cu, Ti, Zn) and polyphenol (tannic acid, gallic acid, quercetin, pyrogallic acid) could be incorporated into this hydrogel framework. As a demonstration, the chitin-tannic acid-Cu hydrogel showed excellent antibacterial properties and significantly enhanced infected wound repair via promoting the cell proliferation and angiogenesis, showing the potential in wound dressing. The low cost, versatility and flexibility assembly process can be used to fabricate diverse polymer-polyphenol-metal hydrogel, thereby enabling their use in various applications.
金属-多酚网络由于其显著的特性而引起了人们对各种生物医学应用的关注。尽管已经制备了各种金属-多酚材料，但均相金属-多酚基水凝胶的制备仍然是一个挑战（例如，快速聚集）。在此，开发了一种简便且低成本的多酚介导的非共价驱动力组装策略，用于制备均相甲壳素-多酚-金属水凝胶。多酚不仅可以非共价交联壳聚糖链，而且可以同时从金属基底捕获金属纳米材料并固定在壳聚糖-多酚网络中。一系列金属（Fe、Cu、Ti、Zn）和多酚（单宁酸、没食子酸、槲皮素、焦性没食子酸）可以掺入这种水凝胶骨架中。作为一个实例，甲壳素-单宁酸-Cu 水凝胶表现出优异的抗菌性能，并通过促进细胞增殖和血管生成显著增强感染伤口的修复，显示出在伤口敷料中的应用潜力。低成本、多功能和灵活的组装工艺可用于制造各种聚合物-多酚-金属水凝胶，从而使其在各种应用中得到应用。
