Cluster for Advanced Macromolecular Design, Australian Centre for Nanomedicine, School of Chemical Engineering, The University of New South Wales, 2052, Sydney, NSW, Australia.
Angew Chem Int Ed Engl. 2023 Jun 19;62(25):e202302451. doi: 10.1002/anie.202302451. Epub 2023 Apr 27.
We report an aqueous and near-infrared (NIR) light mediated photoinduced reversible addition-fragmentation chain transfer (photo-RAFT) polymerization system catalyzed by tetrasulfonated zinc phthalocyanine (ZnPcS ) in the presence of peroxides. Taking advantage of its fast polymerization rates and high oxygen tolerance, this system is successfully applied for the preparation of hydrogels. Exploiting the enhanced penetration of NIR light, photoinduced gelation is effectively performed through non-transparent biological barriers. Notably, the RAFT agents embedded in these hydrogel networks can be reactivated on-demand, enabling the hydrogel healing under NIR light irradiation. In contrast to the minimal healing capability (<15 %) of hydrogels prepared by free radical polymerization (FRP), RAFT-mediated networks display more than 80 % recovery of tensile strength. Although healable polymer networks under UV and blue lights have already been established, this work is the first photochemistry system using NIR light, facilitating photoinduced healing of hydrogels through thick non-transparent barriers.
我们报告了一种在四磺化锌酞菁（ZnPcS ）存在下，过氧化物催化的水相和近红外（NIR）光介导的光诱导可逆加成-断裂链转移（photo-RAFT）聚合体系。利用其快速聚合速率和高耐氧性，成功地将该体系应用于水凝胶的制备。利用 NIR 光的增强穿透性，可通过不透明的生物屏障有效地进行光诱导凝胶化。值得注意的是，这些水凝胶网络中嵌入的 RAFT 试剂可以按需重新激活，从而可以在 NIR 光照射下实现水凝胶的愈合。与由自由基聚合（FRP）制备的水凝胶的最小愈合能力（<15%）相比，RAFT 介导的网络显示出超过 80%的拉伸强度恢复。尽管已经建立了可紫外光和蓝光下愈合的聚合物网络，但这项工作是首次使用 NIR 光的光化学系统，通过厚的不透明屏障实现了水凝胶的光诱导愈合。
