Farasati Far Bahareh, Safaei Maryam, Nahavandi Reza, Gholami Amir, Naimi-Jamal Mohammad Reza, Tamang Sujina, Ahn Jung Eun, Ramezani Farani Marzieh, Huh Yun Suk
Department of Chemistry, Iran University of Science and Technology, Tehran 13114-16846, Iran.
Department of Pharmacology, Faculty of Pharmacy, Eastern Mediterranean University, via Mersin 10, Famagusta, TR. North Cyprus 99628, Turkey.
ACS Omega. 2024 Jun 24;9(27):29139-29158. doi: 10.1021/acsomega.3c10102. eCollection 2024 Jul 9.
Hydrogel encapsulation is a promising carrier for cell and drug delivery due to its ability to protect the encapsulated entities from harsh physiological conditions and enhance their therapeutic efficacy and bioavailability. However, there is not yet consensus on the optimal hydrogel type, encapsulation method, and clinical application. Therefore, a systematic review of hydrogel encapsulation techniques and their potential for clinical application is needed to provide a comprehensive and up-to-date overview. In this systematic review, we searched electronic databases for articles published between 2008 and 2023 that described the encapsulation of cells or drug molecules within hydrogels. Herein, we identified 9 relevant studies that met the inclusion and exclusion criteria of our study. Our analysis revealed that the physicochemical properties of the hydrogel, such as its porosity, swelling behavior, and degradation rate, play a critical role in the encapsulation of cells or drug molecules. Furthermore, the encapsulation method, including physical, chemical, or biological methods, can affect the encapsulated entities' stability, bioavailability, and therapeutic efficacy. Challenges of hydrogel encapsulation include poor control over the release of encapsulated entities, limited shelf life, and potential immune responses. Future directions of hydrogel encapsulation include the development of novel hydrogel and encapsulation methods and the integration of hydrogel encapsulation with other technologies, such as 3D printing and gene editing. In conclusion, this review is useful for researchers, clinicians, and policymakers who are interested in this field of drug delivery and regenerative medicine that can serve as a guide for the future development of novel technologies that can be applied into clinical practice.
水凝胶包封作为一种有前景的细胞和药物递送载体，因其能够保护被包封的物质免受恶劣生理条件的影响，并提高其治疗效果和生物利用度。然而，对于最佳水凝胶类型、包封方法和临床应用尚未达成共识。因此，需要对水凝胶包封技术及其临床应用潜力进行系统综述，以提供全面和最新的概述。在这项系统综述中，我们在电子数据库中搜索了2008年至2023年期间发表的描述细胞或药物分子在水凝胶中包封的文章。在此，我们确定了9项符合我们研究纳入和排除标准的相关研究。我们的分析表明，水凝胶的物理化学性质，如孔隙率、溶胀行为和降解速率，在细胞或药物分子的包封中起着关键作用。此外，包封方法，包括物理、化学或生物学方法，会影响被包封物质的稳定性、生物利用度和治疗效果。水凝胶包封面临的挑战包括对被包封物质释放的控制不佳、保质期有限以及潜在的免疫反应。水凝胶包封的未来发展方向包括新型水凝胶和包封方法的开发，以及水凝胶包封与其他技术（如3D打印和基因编辑）的整合。总之，本综述对该药物递送和再生医学领域感兴趣的研究人员、临床医生和政策制定者有用，可作为未来可应用于临床实践的新技术发展的指南。
