《生物化学论文集》关于结构质谱的特刊。
A special issue of Essays in Biochemistry on structural mass spectrometry.
机构信息
Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3QZ, U.K.
The Kavli Institute for Nanoscience Discovery, Sherrington Road, Oxford OX1 3QU, U.K.
出版信息
Essays Biochem. 2023 Mar 29;67(2):147-149. doi: 10.1042/EBC20230006.
Mass spectrometry (MS) is now established as an analytical tool to interrogate the structure and dynamics of proteins and their assemblies. An array of MS-based technologies has been developed, with each providing unique information pertaining to protein structure, and forming the heart of integrative structural biology studies. This special issue includes a collection of review articles that discuss both established and emerging structural MS methodologies, along with examples of how these technologies are being deployed to interrogate protein structure and function. Combined, this collection highlights the immense potential of the structural MS toolkit in the study of molecular mechanisms underpinning cellular homeostasis and disease.
质谱（MS）现已成为一种分析工具，用于研究蛋白质及其复合物的结构和动态。已经开发出一系列基于 MS 的技术，每种技术都提供有关蛋白质结构的独特信息，构成了综合结构生物学研究的核心。本期特刊包括一系列综述文章，讨论了已建立和新兴的结构 MS 方法学，以及这些技术如何被用于研究蛋白质结构和功能的实例。这些文章共同强调了结构 MS 工具包在研究细胞内稳态和疾病相关分子机制方面的巨大潜力。
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