Freedy H R, Cetnarowski A B, Lumish R M, Schafer F J
Drug Intell Clin Pharm. 1986 Apr;20(4):281-3. doi: 10.1177/106002808602000413.
A number of recent articles have reviewed the problem of hypoprothrombinemia and bleeding associated with antibiotic therapy. We report three cases in which bleeding is believed to be related to a prolonged prothrombin time secondary to cefoperazone therapy. Reports of coagulopathies such as these are increasing in number and call attention to the need to monitor the prothrombin time during cefoperazone therapy.
最近有一些文章综述了与抗生素治疗相关的低凝血酶原血症和出血问题。我们报告了3例出血被认为与头孢哌酮治疗继发的凝血酶原时间延长有关的病例。这类凝血障碍的报告数量在不断增加，这提醒人们注意在头孢哌酮治疗期间监测凝血酶原时间的必要性。
