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病例报告：单次使用氨基比林后同时发生中性粒细胞减少和溶血性贫血。

Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose.

机构信息

Department of Internal Medicine II, Cardiology, University Medical Center Regensburg, Regensburg, Germany.

Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, University Medical Center Regensburg, Regensburg, Germany.

出版信息

Drugs R D. 2023 Jun;23(2):93-98. doi: 10.1007/s40268-023-00415-9. Epub 2023 Mar 29.

DOI:10.1007/s40268-023-00415-9
PMID:36988798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10293139/
Abstract

BACKGROUND AND OBJECTIVE

Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole.

CASE

Here, we present the case of a 62-year-old patient who developed agranulocytosis as well as hemolysis after a single administration of metamizole.

CONCLUSION

This case illustrates the inherent allergic potential of metamizole and its effects on different hematopoietic cell types.

摘要

背景与目的

甲灭酸是一种非阿片类安替比林磺酸盐化合物，具有强效的镇痛、解热和痉挛缓解作用。粒细胞缺乏症是甲灭酸罕见的致命并发症。

病例报告

本案例报道了一例 62 岁患者，单次使用甲灭酸后出现粒细胞缺乏症和溶血性贫血。

结论

该病例说明了甲灭酸的固有过敏潜力及其对不同造血细胞类型的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b33/10293139/343f4bf27556/40268_2023_415_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b33/10293139/343f4bf27556/40268_2023_415_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b33/10293139/343f4bf27556/40268_2023_415_Fig1_HTML.jpg

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本文引用的文献

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Contrast Media-Induced Immune Hemolytic Anemia.造影剂诱导的免疫性溶血性贫血
Cureus. 2021 Apr 16;13(4):e14522. doi: 10.7759/cureus.14522.
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NAT2 polymorphisms as a cause of metamizole-induced agranulocytosis.NAT2基因多态性是安乃近所致粒细胞缺乏症的一个病因。
Pharmacogenet Genomics. 2021 Aug 1;31(6):140-143. doi: 10.1097/FPC.0000000000000432.
3
Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis.反应性安乃近代谢物通过抑制糖酵解增强氯高铁血红素对HL60细胞ATP池的毒性。
Biomedicines. 2020 Jul 14;8(7):212. doi: 10.3390/biomedicines8070212.
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[Agranulocytosis after use of metamizole - an underestimated risk?].[使用安乃近后发生粒细胞缺乏症——一种被低估的风险？]
Laryngorhinootologie. 2020 Oct;99(10):707-712. doi: 10.1055/a-1190-4445. Epub 2020 Jun 25.
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Metamizole and the risk of drug-induced agranulocytosis and neutropenia in statutory health insurance data.甲灭酸与法定健康保险数据中药物诱导的粒细胞缺乏症和中性粒细胞减少症的风险。
Naunyn Schmiedebergs Arch Pharmacol. 2020 Apr;393(4):681-690. doi: 10.1007/s00210-019-01774-4. Epub 2019 Dec 7.
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Agranulocytosis attributed to metamizole: An analysis of spontaneous reports in EudraVigilance 1985-2017.归因于甲氨蝶呤的粒细胞缺乏症：EudraVigilance 1985-2017 年自发报告分析。
Basic Clin Pharmacol Toxicol. 2020 Feb;126(2):116-125. doi: 10.1111/bcpt.13310. Epub 2019 Oct 7.
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Metamizole (Dipyrone) and the Liver: A Review of the Literature.美他佐辛（双氢可待因酮）与肝脏：文献综述。
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