病例报告：单次使用氨基比林后同时发生中性粒细胞减少和溶血性贫血。
Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose.
机构信息
Department of Internal Medicine II, Cardiology, University Medical Center Regensburg, Regensburg, Germany.
Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, University Medical Center Regensburg, Regensburg, Germany.
出版信息
Drugs R D. 2023 Jun;23(2):93-98. doi: 10.1007/s40268-023-00415-9. Epub 2023 Mar 29.
BACKGROUND AND OBJECTIVE
Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole.
CASE
Here, we present the case of a 62-year-old patient who developed agranulocytosis as well as hemolysis after a single administration of metamizole.
CONCLUSION
This case illustrates the inherent allergic potential of metamizole and its effects on different hematopoietic cell types.
背景与目的
甲灭酸是一种非阿片类安替比林磺酸盐化合物，具有强效的镇痛、解热和痉挛缓解作用。粒细胞缺乏症是甲灭酸罕见的致命并发症。
病例报告
本案例报道了一例 62 岁患者，单次使用甲灭酸后出现粒细胞缺乏症和溶血性贫血。
结论
该病例说明了甲灭酸的固有过敏潜力及其对不同造血细胞类型的影响。
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