Integrated Bioprocessing Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603203, India.
Department of Biochemistry, FASCM, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu 641021, India.
Bioresour Technol. 2023 Jun;378:128975. doi: 10.1016/j.biortech.2023.128975. Epub 2023 Mar 27.
The progress of versatile chemicals and bio-based fuels using renewable biomass has gained ample importance. Furfural and 5-hydroxymethylfurfural are biomass-derived compounds that serve as the cornerstone for high-value chemicals and have a myriad of industrial applications. Despite the significant research into several chemical processes for furanic platform chemicals conversion, the harsh reaction conditions and toxic by-products render their biological conversion an ideal alternative strategy. Although biological conversion confers an array of advantages, these processes have been reviewed less. This review explicates and evaluates notable improvements in the bioconversion of 5-hydroxymethylfurfural and furfural to comprehend the current developments in the biocatalytic transformation of furan. Enzymatic conversion of HMF and furfural to furanic derivative have been explored, while the latter has substantially overlooked a foretime. This discrepancy was reviewed along with the outlook on the potential usage of 5-hydroxymethylfurfural and furfural for the furan-based value-added products' synthesis.
利用可再生生物质生产多功能化学品和生物基燃料的进展受到了广泛关注。糠醛和 5-羟甲基糠醛是生物质衍生的化合物，它们是高价值化学品的基石，具有广泛的工业应用。尽管已经对多种糠醛平台化学品转化的化学工艺进行了大量研究，但苛刻的反应条件和有毒副产物使得它们的生物转化成为一种理想的替代策略。虽然生物转化具有许多优势，但这些过程的研究相对较少。本文详细阐述和评估了 5-羟甲基糠醛和糠醛生物转化方面的显著改进，以了解呋喃的生物催化转化的最新发展。已经探索了酶法转化 HMF 和糠醛为呋喃衍生物，而后者在以前的研究中被大大忽视了。本文综述了这种差异，并展望了 5-羟甲基糠醛和糠醛在基于呋喃的增值产品合成中的潜在用途。
