Kim Jinyi, Lee Changju, Kang Youbin, Kang Wooyoung, Kim Aram, Tae Woo-Suk, Ham Byung-Joo, Chang Jisoon, Han Kyu-Man
Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital, Seoul, Republic of Korea.
Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Psychiatry Investig. 2023 Mar;20(3):255-261. doi: 10.30773/pi.2022.0314. Epub 2023 Mar 22.
A growing body of evidence reports on the effect of different types of childhood abuse on the structural and functional architecture of the brain. In the present study, we aimed to investigate the differences in cortical thickness according to specific types of childhood abuse between patients with major depressive disorder (MDD) and healthy controls (HCs).
A total of 61 patients with MDD and 98 HCs were included in this study. All participants underwent T1-weighted magnetic resonance imaging, and the occurrence of childhood abuse was assessed using the Childhood Trauma Questionnaire. We investigated the association between whole-brain cortical thickness and exposure to any type of childhood abuse and specific type of childhood abuse in the total sample using the FreeSurfer software.
No significant difference was reported in the cortical thickness between the MDD and HC groups nor between the "any abuse" and "no abuse" groups. Compared to no exposure to childhood sexual abuse (CSA), exposure to CSA was significantly associated with cortical thinning in the left rostral middle frontal gyrus (p=0.00020), left (p=0.00240), right fusiform gyri (p=0.00599), and right supramarginal gyrus (p=0.00679).
Exposure to CSA may lead to cortical thinning of the dorsolateral prefrontal cortex, which is deeply involved in emotion regulation, to a greater extent than other types of childhood abuse.
越来越多的证据报道了不同类型的童年期虐待对大脑结构和功能结构的影响。在本研究中，我们旨在调查重度抑郁症（MDD）患者与健康对照者（HCs）之间，根据特定类型的童年期虐待所导致的皮质厚度差异。
本研究共纳入61例MDD患者和98例HCs。所有参与者均接受了T1加权磁共振成像检查，并使用儿童创伤问卷评估童年期虐待的发生情况。我们使用FreeSurfer软件在总样本中研究全脑皮质厚度与任何类型的童年期虐待以及特定类型的童年期虐待之间的关联。
MDD组与HC组之间，以及“有任何虐待”组与“无虐待”组之间的皮质厚度均未报告有显著差异。与未遭受童年期性虐待（CSA）相比，遭受CSA与左侧额中回喙部（p = 0.00020）、左侧（p = 0.00240）、右侧梭状回（p = 0.00599）和右侧缘上回（p = 0.00679）的皮质变薄显著相关。
与其他类型的童年期虐待相比，遭受CSA可能会导致背外侧前额叶皮质的皮质变薄，而背外侧前额叶皮质在情绪调节中起着重要作用。
